Evidence map›Paper›PMID 25015413›Full record

Observational studyBMC pregnancy and childbirth2014

The Belgian Diabetes in Pregnancy Study (BEDIP-N), a multi-centric prospective cohort study on screening for diabetes in pregnancy and gestational diabetes: methodology and design.

Katrien Benhalima, Paul Van Crombrugge, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Els Dufraimont, Christophe De Block, Yves Jacquemyn, Farah Mekahli and 3 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in BMC pregnancy and childbirth, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02036619 (Prospective and Multi-centric Study on Diabetes During Pregnancy in Belgium), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02036619 completednot on this map

Prospective and Multi-centric Study on Diabetes During Pregnancy in Belgium

TypeobservationalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2014 to 2018Enrolled2,006ConditionsGestational Diabetes, Diabetes
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
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  3. Article
  4. Observational
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  8. Article
  9. Pregestational Diabetes and Congenital Heart Defects.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Katrien BenhalimaDepartment of Endocrinology and Department of Obstetrics & Gynecology, UZ Gasthuisberg, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. katrien.benhalima@uzleuven.be.
Paul Van Crombrugge
Johan Verhaeghe
Sofie Vandeginste
Hilde Verlaenen
Chris Vercammen
Els Dufraimont
Christophe De Block
Yves Jacquemyn
Farah Mekahli
Katrien De Clippel
Roland Devlieger
Chantal Mathieu
KU Leuven · BEOnze Lieve Vrouwziekenhuis Hospital · BEGZA Ziekenhuizen Campus Sint-Augustinus · BEImelda Hospital · BEUniversitair Ziekenhuis Brussel · BEUniversitair Ziekenhuis Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe International Association of Diabetes and Pregnancy Study Groups (IADPSG) recommends universal screening with a 75 g oral glucose tolerance test (OGTT) using stricter criteria for gestational diabetes (GDM). This may lead to important increases in the prevalence of GDM and associated costs, whereas the gain in health is unclear. The goal of 'The Belgian Diabetes in Pregnancy Study' (BEDIP-N) is to evaluate the best screening strategy for pregestational diabetes in early pregnancy and GDM in an ethnically diverse western European population. The IADPSG screening strategy will be followed, but in addition risk questionnaires and a 50 g glucose challenge test (GCT) will be performed, in order to define the most practical and most cost effective screening strategy in this population.

methodsBEDIP-N is a prospective observational cohort study in 6 centers in Belgium. The aim is to enroll 2563 pregnant women in the first trimester with a singleton pregnancy, aged 18-45 years, without known diabetes and without history of bariatric surgery. Women are universally screened for overt diabetes and GDM in the first trimester with a fasting plasma glucose and for GDM between 24-28 weeks using the 50 g GCT and independently of the result of the GCT, all women will receive a 75 g OGTT using the IADPSG criteria. Diabetes and GDM will be treated according to a standardized routine care protocol. Women with GDM, will be reevaluated three months postpartum with a 75 g OGTT. At each visit blood samples are collected, anthropometric measurements are obtained and self-administered questionnaires are completed. Recruitment began in April 2014. DISCUSSION: This is the first large, prospective cohort study rigorously assessing the prevalence of diabetes in early pregnancy and comparing the impact of different screening strategies with the IADPSG criteria on the detection of GDM later in pregnancy.

trial registrationClinicalTrials.gov: NCT02036619. Registered 14-1-2014.

Indexed as

Research DesignAdolescentAdultBelgiumBlood GlucoseDiabetes, GestationalDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestHumansInflammationLipidsMiddle AgedPractice Guidelines as TopicPregnancyPregnancy in DiabeticsBlood GlucoseLipidsThyrotropinThyroxine

Identifiers

PMID25015413
PMCPMC4227277
OpenAlexW2069269050

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.