Evidence map›Paper›PMID 25015264›Full record

ArticleMolecular biology reports2014

Expression pattern of hTERT telomerase subunit gene in different stages of chronic myeloid leukemia.

Ali Amini, Seyed Hamidollah Ghaffari, Yousef Mortazavi, Yousef Mortazai, Karim Daliri, Shahrouz Taranejoo, Kamran Alimoghadam, Ardeshir Ghavamzadeh

Erratum issuedAbstract read
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In one paragraph

Article in Molecular biology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Ali Amini
Seyed Hamidollah Ghaffari
Yousef Mortazavi
Yousef Mortazai
Karim Daliri
Shahrouz Taranejoo
Kamran Alimoghadam
Ardeshir Ghavamzadeh
Tehran University of Medical Sciences · IRMonash University · AUShahid Sadoughi University of Medical Sciences and Health Services · IRShiraz University of Medical Sciences · IRZanjan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomerase is activated in chronic myeloid leukemia (CML); however, it is not known whether the catalytic telomerase reverse transcriptase subunit (hTERT) is vital in the progression of this disease. This study involved patients with CML in the chronic phase (pretreatment and after treatment), accelerated and blastic phase. Expression of the hTERT gene differed significantly among the four major groups (p < 0.05). We also compared hTERT expression according to demographic parameter such as age and sex, and found no significant differences (p > 0.05). Taken together, our findings suggest the importance of hTERT as a valuable molecular marker in the follow-up of patients with CML, which may have clinical implications for the prognosis.

Indexed as

AdultFemaleGene Expression Regulation, NeoplasticGenetic MarkersHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMalePrognosisRNA, MessengerTelomeraseGenetic MarkersRNA, MessengerTelomerase

Identifiers

PMID25015264
OpenAlexW2057129753

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.