ArticleBMC microbiology2014
Multiresistant extended-spectrum β-lactamase-producing Enterobacteriaceae from humans, companion animals and horses in central Hesse, Germany.
Article in BMC microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed, 175 citations in OpenAlex.
- The Public Health Risks of Colistin Resistance in Dogs and Cats: A One Health Perspective Review.Antibiotics (Basel, Switzerland) · 2025Review
- Pandemic human-associated extended-spectrum β-lactamase-producing Escherichia coli lineages of ST38, ST131 and ST141 identified in Viennese dogs.The Journal of antimicrobial chemotherapy · 2025Article
- Molecular Characterization of PresumptivePathogens (Basel, Switzerland) · 2025Article
- Antimicrobial resistance patterns of multidrug resistant ESBL-producingIranian journal of veterinary research · 2025Article
- Fecal Carriage and Risk Factors Associated with Extended-Spectrum β-Lactamase-/AmpC-/Carbapenemase-ProducingAnimals : an open access journal from MDPI · 2024Article
- The genetic relationship between human and pet isolates: a core genome multilocus sequence analysis of multidrug-resistant bacteria.Antimicrobial resistance and infection control · 2024Article
- Characterizing the bacteriophage PKp-V1 as a potential treatment for ESBL-producing hypervirulent K1Veterinary world · 2024Article
- Transmission dynamics of ESBL/AmpC and carbapenemase-producing Enterobacterales between companion animals and humans.Frontiers in microbiology · 2024Article
- Pharmacokinetics and relative bioavailability study of two cefquinome sulfate intramammary infusions in cow milk.Frontiers in veterinary science · 2024Article
- Drivers of Antibiotic Resistance Gene Abundance in an Urban River.Antibiotics (Basel, Switzerland) · 2023Article
- Evaluation of Potential Factors Influencing the Dissemination of Multidrug-ResistantTropical medicine and infectious disease · 2023Review
- Current Situation of Bacterial Infections and Antimicrobial Resistance Profiles in Pet Rabbits in Spain.Veterinary sciences · 2023Article
- Equine Gram-Negative Oral Microbiota: An Antimicrobial Resistances Watcher?Antibiotics (Basel, Switzerland) · 2023Article
- Carriage of Extended Spectrum Beta Lactamase-ProducingAnimals : an open access journal from MDPI · 2023Article
- Gut colonization and subsequent infection of neonates caused by extended-spectrum beta-lactamase-producingFrontiers in cellular and infection microbiology · 2023Article
- Article
- Comparative Analysis of Phylogenetic Relationships and Virulence Factor Characteristics between Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolates Derived from Clinical Sites and Chicken Farms.Microbiology spectrum · 2022Article
- Integrated surveillance of extended-spectrum beta-lactamase (ESBL)-producingEpidemiology and infection · 2022Article
- Carbapenem resistance in critically important human pathogens isolated from companion animals: a systematic literature review.Osong public health and research perspectives · 2022Article
- Detecting Carbapenemases in Animal and Food Samples by Droplet Digital PCR.Antibiotics (Basel, Switzerland) · 2022Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiresistant Gram-negative bacteria producing extended-spectrum β-lactamases (ESBLs) are an emerging problem in human and veterinary medicine. This study focused on comparative molecular characterization of β-lactamase and ESBL-producing Enterobacteriaceae isolates from central Hesse in Germany. Isolates originated from humans, companion animals (dogs and cats) and horses.
resultsIn this study 153 (83.6%) of the human isolates (n = 183) and 163 (91.6%) of the animal isolates (n = 178) were confirmed as ESBL producers by PCR and subsequent sequencing of the PCR amplicons. Predominant ESBL subtypes in human and animal samples were CTX-M-15 (49.3%) and CTX-M-1 (25.8%) respectively. Subtype blaCTX-M-2 was found almost exclusively in equine and was absent from human isolates. The carbapenemase OXA-48 was detected in 19 ertapenem-resistant companion animal isolates in this study. The Plasmid-encoded quinolone resistance (PMQR) gene aac('6)-Ib-cr was the most frequently detected antibiotic- resistance gene present in 27.9% of the human and 36.9% of the animal ciprofloxacin-resistant isolates. Combinations of two or up to six different resistance genes (penicillinases, ESBLs and PMQR) were detected in 70% of all isolates investigated. The most frequent species in this study was Escherichia coli (74%), followed by Klebsiella pneumoniae (17.5%), and Enterobacter cloacae (4.2%). Investigation of Escherichia coli phylogenetic groups revealed underrepresentation of group B2 within the animal isolates.
conclusionsIsolates from human, companion animals and horses shared several characteristics regarding presence of ESBL, PMQR and combination of different resistance genes. The results indicate active transmission and dissemination of multi-resistant Enterobacteriaceae among human and animal populations.
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