Evidence map›Paper›PMID 25014535›Full record

ArticleMolecules (Basel, Switzerland)2014

Synthesis of a 2"-deoxy-β-GalCer.

Meena S Thakur, Archana Khurana, Mitchell Kronenberg, Amy R Howell

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Meena S ThakurDepartment of Chemistry, University of Connecticut, 55 N. Eagleville Rd., Storrs, CT 06269, USA.
Archana KhuranaLa Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Mitchell KronenbergLa Jolla Institute of Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.
Amy R HowellDepartment of Chemistry, University of Connecticut, 55 N. Eagleville Rd., Storrs, CT 06269, USA. amy.howell@uconn.edu.
La Jolla Institute for Immunology · USUniversity of Connecticut · US

Funding

Development and Function of NKT CellsR37AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2006 to 2015
$4.9M
Recognition of bacterial antigens by NKT cellsR01AI045053 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2000 to 2010
$3.3M
PHOSPHOLIPASES AND THE PATHOGENESIS OF LISTERIA MONOCYTOR01AI045153 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GOLDFINE, HOWARD · 2000 to 2004
$1.4M
Harnessing NKT Cell Activation by GlycolipidsR01GM087136 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI HOWELL, AMY · 2009 to 2010
$536k
NIAID NIH HHS R01 AI045053NIAID NIH HHS R01 AI045153NIAID NIH HHS R01 AI45153NIAID NIH HHS R37 AI071922NIGMS NIH HHS R01 GM087136
6 · The paper itself

Abstract

Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and the T cell receptors. However, these structures alone do not reveal the relative importance of these interactions. This study focuses on the synthesis of the previously unknown 2"-deoxy-β-galactosyl ceramide 2. This glycolipid is also evaluated for its ability to stimulate iNKT cells and sulfatide-reactive Type II NKT cells.

Indexed as

AnimalsAntigens, CD1dGalactosylceramidesInterleukin-2MiceNatural Killer T-CellsAntigens, CD1dGalactosylceramidesInterleukin-2

Identifiers

PMID25014535
PMCPMC4409828
OpenAlexW2018672545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.