ArticleThe Journal of experimental medicine1989
Functional immunoglobulin light chain genes are replaced by ongoing rearrangements of germline V kappa genes to downstream J kappa segment in a murine B cell line.
Article in The Journal of experimental medicine, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Receptor selection in B and T lymphocytes.Annual review of immunology · 2000Review
- Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas.The Journal of experimental medicine · 1999Article
- Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.The Journal of clinical investigation · 1997Article
- Light chain editing in kappa-deficient animals: a potential mechanism of B cell tolerance.The Journal of experimental medicine · 1994Article
- Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.The Journal of experimental medicine · 1993Article
- Receptor editing: an approach by autoreactive B cells to escape tolerance.The Journal of experimental medicine · 1993Article
- B lymphocytes may escape tolerance by revising their antigen receptors.The Journal of experimental medicine · 1993Article
- Immunotherapy of B lymphoma by anti-idiotype antibodies: characterization of variant tumour cells appearing a long time after the initial tumour inoculation.Cancer immunology, immunotherapy : CII · 1991Article
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Authors and funding
3 authors.
Funding
Abstract
A murine B cell lymphoma (38C13) was subjected to immunoselection with mAbs directed against the idiotypic determinants of its cell surface Ig. Variants emerged with altered Ig receptors containing identical heavy chains but different light chains. The functional light chain genes in these variants were composed of V kappa segments drawn from the V kappa Ox-1 family, which had replaced the V kappa gene expressed by the parental tumor by rearranging to downstream J kappa segments. Rearrangement at the kappa locus continued to occur spontaneously, giving rise to secondary and tertiary variants at a rate of 1.9 x 10(-4) per cell per generation. Variants were isolated that had ceased production of surface Ig but went on to rearrange again and to become surface Ig+. The Ig- state may be an intermediate step providing a stimulus for continued rearrangement. This process provides an additional mechanism for generating diversity within B cell clones and expands the use of the available repertoire of Ig genes.
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