ArticleBiochemistry2014
Structured cyclic peptides that bind the EH domain of EHD1.
Article in Biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Identification and functional validation of EPS15L1 as a key driver of triple-negative breast cancer.NPJ breast cancer · 2026Article
- Elucidating Solution Structures of Cyclic Peptides Using Molecular Dynamics Simulations.Chemical reviews · 2021Review
- NF-κB-driven improvement of EHD1 contributes to erlotinib resistance in EGFR-mutant lung cancers.Cell death & disease · 2018Article
- Thioether-stapled macrocyclic inhibitors of the EH domain of EHD1.Bioorganic & medicinal chemistry · 2018Article
- Conformational Restriction of Peptides Using Dithiol Bis-Alkylation.Methods in enzymology · 2016Article
- Molecular dynamics simulation of the interactions between EHD1 EH domain and multiple peptides.Journal of Zhejiang University. Science. B · 2015Article
- Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli.Chembiochem : a European journal of chemical biology · 2015Article
- Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria.The Journal of biological chemistry · 2015Article
- Increased Expression of Eps15 Homology Domain 1 is Associated with Poor Prognosis in Resected Small Cell Lung Cancer.Journal of Cancer · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
EHD1 mediates long-loop recycling of many receptors by forming signaling complexes using its EH domain. We report the design and optimization of cyclic peptides as ligands for the EH domain of EHD1. We demonstrate that the improved affinity from cyclization allows fluorescence-based screening applications for EH domain inhibitors. The cyclic peptide is also unusually well-structured in aqueous solution, as demonstrated using nuclear magnetic resonance-based structural models. Because few EH domain inhibitors have been described, these more potent inhibitors will improve our understanding of the roles of EHD1 in the context of cancer invasion and metastasis.
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Registered trials
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