Observational studyFunctional neurology
An observational retrospective/horizontal study to compare oxygen-ozone therapy and/or global postural re-education in complicated chronic low back pain.
Observational study in Functional neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- [Effectiveness of ozone therapy compared to other therapies for low back pain: a systematic review with meta-analysis of randomized clinical trials].Brazilian journal of anesthesiology (Elsevier)Pooled it
- The effects of ultrasound-guided corticosteroid injection compared to oxygen-ozone (OClinical rheumatology · 2018Trial
- Simultaneous pneumocephalus and meningitis as a complication of ozone therapy.Northern clinics of Istanbul · 2026Article
- Effects of Global Postural Re-Education Versus Specific Therapeutic Exercises on Pain, Head Posture, and Pain-Related Psychosocial Factors in Women with Chronic Nonspecific Neck Pain: A Randomized Clinical Trial.Journal of clinical medicine · 2025Article
- Effectiveness of ozone nucleolysis in alleviating pain and enhancing function in lumbar sciatica due to disc herniation: a minimally invasive approach.Clinical rheumatology · 2025Article
- How Effective is Ozone Therapy in Treatment of Lumbar Disc Disease: a Systematic Review of Prospective Studies.Maedica · 2024Article
- Efficacy of Medical Ozone as an Adjuvant Treatment in Dogs with Intervertebral Disc Protusions-A Retrospective Study.Animals : an open access journal from MDPI · 2023Article
- The clinical efficacy of ozone combined with steroid in the treatment of discogenic low back pain: a randomized, double-blinded clinical study.Frontiers in neurology · 2023Article
- Oxygen-Ozone Therapy for Reducing Pro-Inflammatory Cytokines Serum Levels in Musculoskeletal and Temporomandibular Disorders: A Comprehensive Review.International journal of molecular sciences · 2022Review
- Effects of Global Postural Reeducation versus Specific Therapeutic Neck Exercises on Pain, Disability, Postural Control, and Neuromuscular Efficiency in Women with Chronic Nonspecific Neck Pain: Study Protocol for a Randomized, Parallel, Clinical Trial.International journal of environmental research and public health · 2021Article
- Influence of pain-related psychological factors on therapeutic outcomes in patients with chronic low back pain after oxygen-ozone treatment: a case-series.European journal of translational myology · 2021Article
- Ultrasound-guided periradicular oxygen-ozone injections as a treatment option for low back pain associated with sciatica.International orthopaedics · 2021Article
- Oxygen-Ozone Therapy in the Rehabilitation Field: State of the Art on Mechanisms of Action, Safety and Effectiveness in Patients with Musculoskeletal Disorders.Biomolecules · 2021Review
- Integration of focal vibration and intra-articular oxygen-ozone therapy in rehabilitation of painful knee osteoarthritis.The Journal of international medical research · 2021Article
- Metanalysis on the effectiveness of low back pain treatment with oxygen-ozone mixture: Comparison between image-guided and non-image-guided injection techniques.European journal of radiology open · 2021Review
- The effect of ozone injection within a common peroneal nerve schwannoma: A mistreatment due to a misdiagnosis.Surgical neurology international · 2020Article
- Application of ozone therapy in interventional medicine.Journal of interventional medicine · 2019Article
- Intramuscular oxygen-ozone therapy in the treatment of low back pain.Acta bio-medica : Atenei Parmensis · 2018Article
- Intra-articular ozone or hyaluronic acid injection: Which one is superior in patients with knee osteoarthritis? A 6-month randomized clinical trial.Journal of pain research · 2018Article
- Effects of medical ozone upon healthy equine joints: Clinical and laboratorial aspects.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute low back pain (LBP) is the fifth most common reason for physician visits and about nine out of ten adults experience back pain at some point in their life. In a large number of patients LBP is associated with disc herniation (DH). Recently, oxygen-ozone (O2O3) therapy has been used successfully in the treatment of LBP, reducing pain after the failure of other conservative treatments. The aim of this study was to assess the effects of O2O3 therapy in back pain rehabilitation, comparing three groups of patients suffering from chronic back pain associated with DH submitted to three different treatments: intramuscular O2O3 infiltrations, global postural An observational retrospective/horizontal study to compare oxygen-ozone therapy and/or global postural re-education in complicated chronic low back pain re-education (GPR), or a combination of the two (O2O3+GPR). The data show that pain severity before treatment was significantly lower in the patients treated with GPR alone (VAS score 7.4) than in the O2O3+GPR patients (VAS score 8.5) and the O2O3 patients (VAS score 8.6). At the end of treatment, pain severity was lower in the O2O3 patients than in the GPR-alone patients. After some years of follow-up only the difference between O2O3+GPR and GPR-alone remained significant.
Indexed as
Identifiers
25014047PMC4172245W2070074693What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.