ArticlePloS one2014
Water molecular system dynamics associated with amyloidogenic nucleation as revealed by real time near infrared spectroscopy and aquaphotomics.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Low-Temperature Stress-Induced Changes in Cucumber Plants-A Near-Infrared Spectroscopy and Aquaphotomics Approach for Investigation.Sensors (Basel, Switzerland) · 2025Article
- C-reactive protein (CRP) evaluation in human urine using optical sensor supported by machine learning.Scientific reports · 2024Article
- Selective Tumor Hypoxia Targeting Using M75 Antibody Conjugated Photothermally Active MoOACS omega · 2023Article
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- Pilot Aquaphotomic Study of the Effects of Audible Sound on Water Molecular Structure.Molecules (Basel, Switzerland) · 2022Article
- Identification of Stingless Bee Honey Adulteration Using Visible-Near Infrared Spectroscopy Combined with Aquaphotomics.Molecules (Basel, Switzerland) · 2022Article
- Aquaphotomics monitoring of strawberry fruit during cold storage - A comparison of two cooling systems.Frontiers in nutrition · 2022Article
- Real-Time Monitoring of Yogurt Fermentation Process by Aquaphotomics Near-Infrared Spectroscopy.Sensors (Basel, Switzerland) · 2020Article
- A Novel Tool for Visualization of Water Molecular Structure and Its Changes, Expressed on the Scale of Temperature Influence.Molecules (Basel, Switzerland) · 2020Article
- Simulated NIR spectra as sensitive markers of the structure and interactions in nucleobases.Scientific reports · 2019Article
- Aquaphotomics-From Innovative Knowledge to Integrative Platform in Science and Technology.Molecules (Basel, Switzerland) · 2019Review
- Essentials of Aquaphotomics and Its Chemometrics Approaches.Frontiers in chemistry · 2018Article
- Monitoring of Water Spectral Pattern Reveals Differences in Probiotics Growth When Used for Rapid Bacteria Selection.PloS one · 2015Article
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Authors and funding
4 authors.
Funding
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Abstract
The formation of amyloid fibrils proceeds via a nucleation-dependent mechanism in which nucleation phase is generally associated with a high free energy resulting in the rate-limiting step. On the basis of this kinetic feature, the nucleation is one of the most crucial phases controlling the pathogenesis of amyloidoses, but little is known about the details of how protein molecules and surrounding environment vary at this stage. Here, we applied near infrared (NIR) spectral monitoring of water structural changes in real time during the nucleation-dependent fibrillation of insulin. Whilst multivariate spectral analysis in the 2050-2350 nm spectral region indicated cross-β formation, characteristic transformations of water structure have been detected in the spectral region 1300-1600 nm corresponding to the first overtone of water OH stretching vibrations. Furthermore, specific water spectral patterns (aquagrams) related to different water molecular conformations have been found along the course of protein nucleation and aggregation. Right in the beginning, dissociation of hydrogen-bonded network in bulk water and coinstantaneous protein and ion hydration were observed, followed by water hydrogen-bonded networks development, presumably forcing the nucleation. These specific transformations of water spectral pattern could be used further as a biomarker for early non-invasive diagnosis of amyloidoses prior to explosive amplification and deposits of amyloid fibrils.
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