ArticleBioMed research international2014
Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11).
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- A Systematic Review of the Literature Examining the Effects of Cigarette Smoke and e-Cigarette Vapor on the Virulence of Human Pathogenic Bacteria.International journal of environmental research and public health · 2022Pooled it
- Natural and synthetic chemicals acting as enhancers of bacterial pathogenic success within the human host.Frontiers in cellular and infection microbiology · 2026Review
- Comparative Effects of Cigarette Smoke and Heated Tobacco Product Aerosols on Biofilm Production by Respiratory Pathogens.Microorganisms · 2025Article
- Effects of Anti-Pseudomonal Agents, Individually and in Combination, With or Without Clarithromycin, on Growth and Biofilm Formation by Antibiotic-Susceptible and -Resistant Strains ofAntibiotics (Basel, Switzerland) · 2025Article
- Gene Expression Regulation in Airway Pathogens: Importance for Otitis Media.Frontiers in cellular and infection microbiology · 2022Review
- Transcriptional Response ofFrontiers in microbiology · 2021Article
- Electronic Cigarette (E-Cigarette) Vapor Exposure Alters the Streptococcus pneumoniae Transcriptome in a Nicotine-Dependent Manner without Affecting Pneumococcal Virulence.Applied and environmental microbiology · 2020Article
- Effects of Cigarette Smoke Condensate on Growth and Biofilm Formation byBioMed research international · 2020Article
- Effect of nicotine on Staphylococcus aureus biofilm formation and virulence factors.Scientific reports · 2019Article
- Electronic cigarette vapour increases virulence and inflammatory potential of respiratory pathogens.Respiratory research · 2019Article
- Cigarette smoke exposure induces expression of the pneumococcal erm(B) macrolide resistance gene.Tobacco induced diseases · 2019Article
- Meningococcal pneumonia: a review.Pneumonia (Nathan Qld.) · 2019Review
- The transcriptomic response of Streptococcus pneumoniae following exposure to cigarette smoke extract.Scientific reports · 2018Article
- Scratching the surface - tobacco-induced bacterial biofilms.Tobacco induced diseases · 2015Article
- Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK).Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P<0.014-0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen.
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