ArticleBioMed research international2014
Intraoperative cerebral glioma characterization with contrast enhanced ultrasound.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Intraoperative contrast-enhanced ultrasound features of progressive multifocal leukoencephalopathy: a case report.Frontiers in neuroimaging · 2026Article
- Advances in Preoperative and Intraoperative Technologies for Safe Resection of Gliomas in Cognitive Regions.Cancers · 2025Review
- In reply: Comment on "Intraoperative superb microvascular ultrasound imaging in glioma: novel quantitative analysis correlates with tumor grade".Acta neurochirurgica · 2025Article
- Complex skull base brain tumor resection: the role of microvascular doppler in surgical precision and outcomes.Frontiers in oncology · 2025Article
- Navigating the challenges: ultrasound innovations in brain glioma surgery.Frontiers in neurology · 2025Review
- Clinical application of intraoperative ultrasound superb microvascular imaging in brain tumors resections: contributing to the achievement of total tumoral resection.BMC medical imaging · 2024Article
- Survival Analysis of Patients Undergoing Intraoperative Contrast-enhanced Ultrasound in the Surgical Treatment of Malignant Glioma.Current medical science · 2024Article
- Progress in the application of ultrasound in glioma surgery.Frontiers in medicine · 2024Review
- Quantitative analysis using intraoperative contrast-enhanced ultrasound in adult-type diffuse gliomas with isocitrate dehydrogenase mutations: association between hemodynamics and molecular features.Ultrasonography (Seoul, Korea) · 2023Article
- Maximal Safe Resection in Glioblastoma Surgery: A Systematic Review of Advanced Intraoperative Image-Guided Techniques.Brain sciences · 2023Review
- Application of intraoperative ultrasound in the resection of high-grade gliomas.Frontiers in neurology · 2023Review
- Theranostics in the vasculature: bioeffects of ultrasound and microbubbles to induce vascular shutdown.Theranostics · 2023Review
- Towards an Established Intraoperative Oncological Favorable Tool: Results of Fluorescein-Guided Resection from a Monocentric, Prospective Series of 93 Primary Glioblastoma Patients.Journal of clinical medicine · 2022Article
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- Brain contrast-enhanced ultrasonography and elastography in infants.Ultrasonography (Seoul, Korea) · 2022Article
- Intraoperative ultrasound in brain tumor surgery: A review and implementation guide.Neurosurgical review · 2022Review
- Review
- Ultrasounds induce blood-brain barrier opening across a sonolucent polyolefin plate in an in vitro isolated brain preparation.Scientific reports · 2022Article
- Application of Intraoperative Contrast-Enhanced Ultrasound in the Resection of Brain Tumors.Current medical science · 2022Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundContrast enhanced ultrasound (CEUS) is a dynamic and continuous modality providing real-time view of vascularization and flow distribution patterns of different organs and tumors. Nevertheless its intraoperative use for brain tumors visualization has been performed few times, and a thorough characterization of cerebral glioma had never been performed before.
aimTo perform the first characterization of cerebral glioma using CEUS and to possibly achieve an intraoperative differentiation of different gliomas.
methodsWe performed CEUS in an off-label setting in 69 patients undergoing surgery for cerebral glioma. An intraoperative qualitative analysis was performed comparing iCEUS with B-mode imaging. A postprocedural semiquantitative analysis was then performed for each case, according to EFSUMB criteria. Results were related to histopathology.
resultsWe observed different CE patterns: LGG show a mild, dotted CE with diffuse appearance and slower, delayed arterial and venous phase. HGG have a high CE with a more nodular, nonhomogeneous appearance and fast perfusion patterns.
conclusionOur study characterizes for the first time human brain glioma with CEUS, providing further insight regarding these tumors' biology. CEUS is a fast, safe, dynamic, real-time, and economic tool that might be helpful during surgery in differentiating malignant and benign gliomas and refining surgical strategy.
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