Evidence map›Paper›PMID 25013603›Full record

ArticleInternational journal of organ transplantation medicine2011

The molecular and antigenic tissue impact of viral infections on liver transplant patients with neonatal hepatitis.

R Yaghobi, B Geramizadeh, S Zamani, M Rahsaz, N Azarpira, M H Karimi, M Ayatolahi, M Hossein Aghdai, S Nikeghbalian, A Bahador and 2 more

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Article in International journal of organ transplantation medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

R YaghobiShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
B GeramizadehShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
S ZamaniShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
M RahsazShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
N AzarpiraShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
M H KarimiShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
M AyatolahiShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
M Hossein AghdaiShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
S NikeghbalianShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, ; Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.
A BahadorShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
H SalahiOrgan Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.
S A Malek-HosseiniShiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, ; Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPathogenesis of neonatal hepatitis relates to various underlying causes including viral infections. Both hepatotropic and non-hepatotropic viruses may induce liver failures in infants before birth, during delivery, or shortly after birth.

objectivesThe tissue impact of HCMV, HSV, HBV, HCV, and rotavirus and adenovirus infections was evaluated in studied infants with neonatal hepatitis.

methodsThe history of viral infections was analyzed in paraffin-embedded biopsy and autopsy tissues of 22 infants with neonatal hepatitis between years 1996 and 2007, retrospectively. The tissue molecular presentation of HBV, HCV, HCMV, HSV, adenovirus, and rotavirus was evaluated by different qualitative simple and nested PCR and RT-PCR protocols. Immunohistochemistry (IHC) method was used for studying the antigenic prevalence of HSV-1, 2; HBV, HCMV and adenovirus infections. Also the laboratory liver indices of all patients with neonatal hepatitis were analyzed.

resultsThe HBV and HSV genomes were detected in 3 (14%) of 22 infants. The rotavirus and HCV-RNA and also the HCMV-DNA were detected separately in 1 (4%) of 26 paraffin-embedded autopsy and biopsy tissues. The HBV and HSV-1 specific antigens were separately diagnosed in 1 (4%) of 26 neonatal samples by IHC protocols. Also the HSV-2 antigen was seen in 5 (23%) of 22 liver autopsy and biopsy specimens. Co-infections with HCMV, HSV, HBV, HCV, and rotavirus were detected in these infants with hepatitis.

conclusionDiagnosis of single and mixed molecular and antigenic traces of HCMV, HSV, HBV, HCV and rotavirus underlines the etiologic role of these viruses in clinical pathogenesis of neonatal hepatitis.

Indexed as

IHCNeonatal hepatitisPCRViral infections

Identifiers

PMID25013603
PMCPMC4089257
OpenAlexW1588285024

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.