ArticleJournal of breast cancer2014
Clinicopathologic characteristics of breast cancer stem cells identified on the basis of aldehyde dehydrogenase 1 expression.
Article in Journal of breast cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- ALDH1A1 in breast cancer: A prospective target to overcome therapy resistance (Review).Oncology letters · 2025Review
- SHP2 Potentiates the Oncogenic Activity of β-Catenin to Promote Triple-Negative Breast Cancer.Molecular cancer research : MCR · 2021Article
- ALDH1+ stem cells demonstrate more stem cell-like characteristics than CD44Translational cancer research · 2020Article
- Article
- Prognostic value of aldehyde dehydrogenase 1 (ALDH1) in invasive breast carcinomas.Bosnian journal of basic medical sciences · 2018Article
- Cancer stem cell markers ALDH1 and CD44+/CD24- phenotype and their prognosis impact in invasive ductal carcinoma.European journal of histochemistry : EJH · 2018Article
- Targeting long non-coding RNA DANCR inhibits triple negative breast cancer progression.Biology open · 2017Article
- Breast cancer stem cells expressing different stem cell markers exhibit distinct biological characteristics.Molecular medicine reports · 2016Article
- In phyllodes tumour of the breast expression of c-kit but not of ALDH1A1 is associated with adverse clinico-pathological features.Virchows Archiv : an international journal of pathology · 2016Article
- MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes.Scientific reports · 2016Article
- Evaluation of Breast Cancer Stem Cells and Intratumor Stemness Heterogeneity in Triple-negative Breast Cancer as Prognostic Factors.International journal of biological sciences · 2016Article
- Aberrant high expression of immunoglobulin G in epithelial stem/progenitor-like cells contributes to tumor initiation and metastasis.Oncotarget · 2015Article
- Targeting MCM2 function as a novel strategy for the treatment of highly malignant breast tumors.Oncotarget · 2015Article
- Proliferation rate and breast cancer subtype, but not ALDH1 expression, predict pathological response to neoadjuvant chemotherapy in locally advanced breast cancer.Virchows Archiv : an international journal of pathology · 2015Article
- Influence of Androgen Receptor Expression on the Survival Outcomes in Breast Cancer: A Meta-Analysis.Journal of breast cancer · 2015Article
- Distinct prognostic values of ALDH1 isoenzymes in breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Prognostic Value of Cancer Stem Cells Markers in Triple-Negative Breast Cancer.BioMed research international · 2015Article
- Aldehyde dehydrogenase 1 expression correlates with clinicopathologic features of patients with breast cancer: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBreast cancer displays varying molecular and clinical features. The ability to form breast tumors has been shown by several studies with aldehyde dehydrogenase 1 (ALDH1) positive cells. The aim of this study is to investigate the association between ALDH1 expression and clinicopathologic characteristics of invasive ductal carcinoma.
methodsWe investigated breast cancer tissues for the prevalence of ALDH1(+) tumor cells and their prognostic value. The present study included paraffin-embedded tissues of 70 patients with or without recurrences. We applied immunohistochemical staining for the detection of ALDH1(+) cells. Analysis of the association of clinical outcomes and molecular subtype with marker status was conducted.
resultsALDH1(+) and ALDH1(-) tumors were more frequent in triple-negative breast cancers and in luminal A breast cancers, respectively (p<0.01). ALDH1 expression was found to exert significant impact on disease free survival (DFS) (ALDH1(+) vs. ALDH1(-), 53.1±6.7 months vs. 79.2±4.7 months; p=0.03) and overall survival (OS) (ALDH1(+) vs. ALDH1(-), 68.5±4.7 months vs. 95.3±1.1 months; p<0.01). In triple-negative breast cancer (TNBC) patients, DFS and OS showed no statistical differences according to ALDH1 expression (ALDH1(+) vs. ALDH1(-), 45.3±9.4 months vs. 81.3±7.4 months, p=0.52; 69.0±7.5 months vs. 91.3±6.3 months, p=0.67). However, non-TNBC patients showed significant OS difference between ALDH1(+) and ALDH1(-) tumors (ALDH1(+) vs. ALDH1(-), 77.6±3.6 months vs. 98.0±1.0 months; p=0.04) with no statistical difference of DFS (ALDH1(+) vs. ALDH1(-), 60.5±8.0 months vs. 81.8±4.6 months; p=0.27).
conclusionOur findings suggest that the expression of ALDH1 in breast cancer may be associated with TNBC and poor clinical outcomes. On the basis of our findings, we propose that ALDH1 expression in breast cancer could be correlated with poor prognosis, and may contribute to a more aggressive cancer phenotype.
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