ArticleJournal of biomedical research2014
Class A scavenger receptor activation inhibits endoplasmic reticulum stress-induced autophagy in macrophage.
Article in Journal of biomedical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Macrophages and autophagy: partners in crime.The FEBS journal · 2025Review
- Macrophage scavenger receptor A1 promotes skeletal muscle regeneration after hindlimb ischemia.Journal of biomedical research · 2024Article
- Molecular Regulation Mechanism of Microglial Autophagy in the Pathology of Alzheimer's Disease.Aging and disease · 2023Review
- The Role of Hydrogen Sulfide Regulation of Autophagy in Liver Disorders.International journal of molecular sciences · 2022Review
- Review
- Grim-19 deficiency promotes decidual macrophage autophagy in recurrent spontaneous abortion.Frontiers in endocrinology · 2022Article
- Exogenous Hydrogen Sulfide Plays an Important Role Through Regulating Autophagy in Ischemia/Reperfusion Injury.Frontiers in molecular biosciences · 2021Review
- Autophagy & Phagocytosis in Neurological Disorders and their Possible Cross-talk.Current neuropharmacology · 2021Review
- Fucoidan antagonizes diet-induced obesity and inflammation in mice.Journal of biomedical research · 2020Article
- Molecular Targets and Related Biologic Activities of Fucoidan: A Review.Marine drugs · 2020Review
- Review
- The Effect of Heat Stress on Autophagy and Apoptosis of Rumen, Abomasum, Duodenum, Liver and Kidney Cells in Calves.Animals : an open access journal from MDPI · 2019Article
- The Effect of Intravenous Infusions of Glutamine on Duodenal Cell Autophagy and Apoptosis in Early-Weaned Calves.Animals : an open access journal from MDPI · 2019Article
- Pathway Analysis of Fucoidan Activity Using a Yeast Gene Deletion Library Screen.Marine drugs · 2019Article
- Review
- Haematoma scavenging in intracerebral haemorrhage: from mechanisms to the clinic.Journal of cellular and molecular medicine · 2018Review
- Into the eyes of bone marrow-derived mesenchymal stem cells therapy for myocardial infarction and other diseases.Stem cell investigation · 2017Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophage death in advanced atherosclerosis promotes plaque necrosis and destabilization. Involvement of autophagy in bulk degradation of cellular components has been recognized recently as an important mechanism for cell survival under endoplasmic reticulum (ER) stress. We previously found that the engagement of class A scavenger receptor (SR-A) triggered JNK-dependent apoptosis in ER-stressed macrophages. However, pro-apoptotic mechanisms mediated by SR-A are not fully understood. Therefore, we sought to see if SR-A mediated apoptosis was associated with autophagy in macrophages. Here, we showed that fucoidan inhibited microtubule-associated protein light chain 3-phospholipid conjugates (LC3-II) formation as well as the number of autophagosomes under ER stress. The inhibition of LC3-II formation was paralleled by the activation of the mTOR pathway, and the inhibition of mTOR allowed LC3-II induction in macrophages treated with thapsigargin plus fucoidan. Furthermore, apoptosis induced by fucoidan was prevented under ER stress by the mTOR inhibitor. We propose that fucoidan, a SR-A agonist, may contribute to macrophage apoptosis during ER stress by inhibiting autophagy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.