ArticleFrontiers in human neuroscience2014
Assessing the effects of common variation in the FOXP2 gene on human brain structure.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- The neuroanatomy of developmental language disorder: a systematic review and meta-analysis.Nature human behaviour · 2024Pooled it
- Gene Expression-Based Lesion-Symptom Mapping:The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The effect of human-specific genetic variants on neuronal spinogenesis.Frontiers in genetics · 2026Review
- A comprehensive in silico analysis of the deleterious nonsynonymous SNPs of human FOXP2 protein.PloS one · 2022Article
- Molecular networks of the FOXP2 transcription factor in the brain.EMBO reports · 2021Review
- FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.Brain imaging and behavior · 2021Article
- The genetic determinants of language network dysconnectivity in drug-naïve early stage schizophrenia.NPJ schizophrenia · 2021Article
- Toward Robust Functional Neuroimaging Genetics of Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Independent Multiple Factor Association Analysis for Multiblock Data in Imaging Genetics.Neuroinformatics · 2019Article
- Functional characterization of two enhancers located downstream FOXP2.BMC medical genetics · 2019Article
- The Association Between Genetic Variation inFrontiers in neuroscience · 2018Article
- Association between forkhead-box P2 gene polymorphism and clinical symptoms in chronic schizophrenia in a Chinese population.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: I. Development and Description of the Pause Marker.Journal of speech, language, and hearing research : JSLHR · 2017Review
- Neurogenetics of developmental dyslexia: from genes to behavior through brain neuroimaging and cognitive and sensorial mechanisms.Translational psychiatry · 2017Review
- Converging evidence does not support GIT1 as an ADHD risk gene.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2015Article
- Enhanced procedural learning of speech sound categories in a genetic variant of FOXP2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Insights into the genetic foundations of human communication.Neuropsychology review · 2015Review
- Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization.Endocrinology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The FOXP2 transcription factor is one of the most well-known genes to have been implicated in developmental speech and language disorders. Rare mutations disrupting the function of this gene have been described in different families and cases. In a large three-generation family carrying a missense mutation, neuroimaging studies revealed significant effects on brain structure and function, most notably in the inferior frontal gyrus, caudate nucleus, and cerebellum. After the identification of rare disruptive FOXP2 variants impacting on brain structure, several reports proposed that common variants at this locus may also have detectable effects on the brain, extending beyond disorder into normal phenotypic variation. These neuroimaging genetics studies used groups of between 14 and 96 participants. The current study assessed effects of common FOXP2 variants on neuroanatomy using voxel-based morphometry (VBM) and volumetric techniques in a sample of >1300 people from the general population. In a first targeted stage we analyzed single nucleotide polymorphisms (SNPs) claimed to have effects in prior smaller studies (rs2253478, rs12533005, rs2396753, rs6980093, rs7784315, rs17137124, rs10230558, rs7782412, rs1456031), beginning with regions proposed in the relevant papers, then assessing impact across the entire brain. In the second gene-wide stage, we tested all common FOXP2 variation, focusing on volumetry of those regions most strongly implicated from analyses of rare disruptive mutations. Despite using a sample that is more than 10 times that used for prior studies of common FOXP2 variation, we found no evidence for effects of SNPs on variability in neuroanatomy in the general population. Thus, the impact of this gene on brain structure may be largely limited to extreme cases of rare disruptive alleles. Alternatively, effects of common variants at this gene exist but are too subtle to be detected with standard volumetric techniques.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.