Evidence map›Paper›PMID 25013351›Full record

ArticleJournal of chemical and pharmaceutical research2012

Molecular determinants of ligand binding at the human histamine H

Tania C Cordova-Sintjago, Lijuan Fang, Martijn Bruysters, Rob Leurs, Raymond G Booth

Open access · greenAbstract read
In one paragraph

Article in Journal of chemical and pharmaceutical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Tania C Cordova-SintjagoDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610 US.
Lijuan FangDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610 US.
Martijn BruystersDepartment of Pharmacochemistry, Vrije Universiteit, Amsterdam, the Netherland.
Rob LeursDepartment of Pharmacochemistry, Vrije Universiteit, Amsterdam, the Netherland.
Raymond G BoothDepartment of Medicinal Chemistry, University of Florida, Gainesville, Florida 32610 US ; Northeastern University Center for Drug Discovery, Boston, Massachusetts 02115, USA.
University of Florida · USVrije Universiteit Amsterdam · NLNortheastern University · US

Funding

Serotonin 5HT2C Agonist Drugs with 5HT2A/2B Antagonist ActivityR01MH081193 · NIMH · UNIVERSITY OF FLORIDA · PI BOOTH, RAYMOND G. · 2008 to 2012
$1.8M
Novel Functionally-Selective Serotonin 5HT2 Drugs for Amphetamines Abuse/DisorderR01DA030989 · NIDA · UNIVERSITY OF FLORIDA · PI BOOTH, RAYMOND G., MORGAN, DRAKE · 2010 to 2014
$1.6M
Novel 5HT2C Agonist Drugs with 5HT2A Antagonist Activity for Cocaine AddictionR01DA023928 · NIDA · UNIVERSITY OF FLORIDA · PI BOOTH, RAYMOND G. · 2007 to 2010
$1.5M
NIDA NIH HHS R01 DA023928NIDA NIH HHS R01 DA030989NIMH NIH HHS R01 MH081193
6 · The paper itself

Abstract

The human histamine H

Indexed as

dockinghomology modelingHuman histamine H1 G protein-coupled receptor (GPCR)molecular dynamicssite-directed mutagenesis

Identifiers

PMID25013351
PMCPMC4085681
OpenAlexW2401189847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.