ArticleAging2014
Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing.
Article in Aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Analysis of Mutational Burden of Mitochondrial Genome in Cells of Different Human Organs and Tissues.Current medicinal chemistry · 2025Review
- Assessing the feasibility of free DNA for disaster victim identification and forensic applications.Scientific reports · 2024Article
- Next-generation sequencing reveals the mitogenomic heteroplasmy in the topmouth culter (Culter alburnus Basilewsky, 1855).Molecular biology reports · 2022Article
- The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs.Stem cell reports · 2021Article
- Detection of high heteroplasmy in complete loggerhead and hawksbill sea turtles mitochondrial genomes using RNAseq.Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis · 2021Article
- Extreme heterogeneity of human mitochondrial DNA from organelles to populations.Nature reviews. Genetics · 2021Review
- Natural and Artificial Mechanisms of Mitochondrial Genome Elimination.Life (Basel, Switzerland) · 2021Review
- Population-specific signatures of intra-individual mitochondrial DNA heteroplasmy and their potential evolutionary advantages.Scientific reports · 2020Article
- Heteroplasmy in the complete chicken mitochondrial genome.PloS one · 2019Article
- Article
- Gut microbiota changes in the extreme decades of human life: a focus on centenarians.Cellular and molecular life sciences : CMLS · 2018Review
- Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine.Clinical science (London, England : 1979) · 2016Review
- Mitochondrial health, the epigenome and healthspan.Clinical science (London, England : 1979) · 2016Review
- Mitophagy plays a central role in mitochondrial ageing.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Reconsidering the Role of Mitochondria in Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Review
- Mitochondrial DNA sequence variation is largely conserved at birth with rare de novo mutations in neonates.American journal of obstetrics and gynecology · 2015Observational
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role that mtDNA heteroplasmy plays in healthy aging, familial longevity and the heritability patterns of low levels heteroplasmy in the elderly are largely unknown. We analyzed the low levels of mtDNA heteroplasmy in blood in a cohort of centenarians, their offspring and a group of offspring of non long‐lived parents, characterized by a less favorable health phenotype. The aims of this study are to: (i) investigate the transmission of low level heteroplasmies in the elderly; (ii) explore the association of heteroplasmy with age and longevity and (iii) investigate heteroplasmy patterns in these three groups. We sequenced a 853 bp mtDNA fragment in 88 individuals to an average coverage of 49334‐fold, using quality control filtering and triplicate PCR analysis to reduce any methodological bias, and we detected 119 heteroplasmic positions with a minor allele frequency≥0.2%. The results indicate that low‐level heteroplasmies are transmitted and maintained within families until extreme age. We did not find any heteroplasmic variant associated with longevity and healthy aging but we identified an unique heteroplasmy profile for each family, based on total level and positions. This familial profile suggests that heteroplasmy may contribute to familial longevity.
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