Evidence map›Paper›PMID 25013117›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias2015

Clinical characterization of mild cognitive impairment as a prodrome to dementia with Lewy bodies.

Christine M Belden, Vickram Kahlon, Michael Malek-Ahmadi, Andrew Tsai, Marwan N Sabbagh

Abstract read
In one paragraph

Article in American journal of Alzheimer's disease and other dementias, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Heterogeneity of dementia with lewy bodies: Insights from clinical presentations, neuropathology, and biomarkers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  3. Article
  4. Ecological validity of cognitive fluctuations in dementia with Lewy bodies.Journal of the International Neuropsychological Society : JINS · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Evolution of diagnostic criteria and assessments for Parkinson's disease mild cognitive impairment.Movement disorders : official journal of the Movement Disorder Society · 2018
    Review
  9. Neuropsychiatric Symptoms in Mild Cognitive Impairment.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017
    Review
  10. Article
  11. Lewy body dementias.Lancet (London, England) · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Christine M BeldenThe Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ, USA.
Vickram KahlonThe Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ, USA.
Michael Malek-AhmadiThe Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ, USA.
Andrew TsaiThe Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ, USA.
Marwan N SabbaghThe Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ, USA marwan.sabbagh@bannerhealth.com.
Banner Sun Health Research Institute · USCenter for Clinical Research (United States) · US

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
PET, APOE & the Preclinical Course of Alzheimer's DiseaseR01AG031581 · NIA · BANNER ALZHEIMER'S INSTITUTE · PI CASELLI, RICHARD J., REIMAN, ERIC MICHAEL · 2008 to 2018
$16.6M
NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG19610NIA NIH HHS R01 AG031581
6 · The paper itself

Abstract

Limited information regarding the specificity of mild cognitive impairment (MCI) as it relates to dementia with Lewy bodies (DLB) exists. Here, we summarize the clinical phenotype of MCI in clinically suspect DLB. Ten patients with a primary diagnosis of MCI and secondary diagnoses of DLB were identified. Patients underwent clinical neurological and neuropsychological evaluation that included application of McKeith criteria. We found parkinsonism and gait abnormality in 9 of the 10 patients; fluctuations in 8 of the 10; and hallucinations and dream enactment behavior in 5 of the 10. Of the 10 cases, 4 were classified as nonamnestic MCI and 6 were amnestic MCI. Of the 10 cases, 9 displayed executive and/or visuospatial dysfunction. Of the 10 cases, 6 have progressed to DLB. Progression of MCI to DLB is not dependent on memory impairment. The presence of core clinical features-parkinsonism and cognitive fluctuations-and predominant executive and visuospatial dysfunction ± memory impairment is suggestive of a prodromal DLB presentation.

Indexed as

Disease ProgressionProdromal SymptomsAgedAged, 80 and overCognitive DysfunctionFemaleHumansLewy Body DiseaseMaleMiddle AgedPhenotypedementia with Lewy bodiesmild cognitive impairmentneuropsychological–cognitive profilesunique clinical features

Identifiers

PMID25013117
PMCPMC4593401
OpenAlexW1974971601

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.