ArticleJournal of assisted reproduction and genetics2014
The effect of progesterone level prior to oocyte retrieval on the numbers of oocytes retrieved and embryo quality in IVF treatment cycles: an analysis of 2,978 cycles.
Article in Journal of assisted reproduction and genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The effect of flexible low-dose GnRH antagonist on pregnancy outcome in the fresh embryo transfer cycle of IVF-ET: a randomized controlled trial.Reproductive biology and endocrinology : RB&E · 2022Trial
- Association Between Post-Trigger Hormones andJournal of clinical gynecology and obstetrics · 2026Article
- Risk of placenta previa in assisted reproductive technology: A Nordic population study with sibling analyses.PLoS medicine · 2025Article
- Multi-omics PGT: re-evaluation of euploid blastocysts for implantation potential based on RNA sequencing.Human reproduction (Oxford, England) · 2024Article
- High progesterone levels on the day after HCG injection has no effect on clinical pregnancy outcomes inFrontiers in endocrinology · 2024Article
- Clinical outcomes of frozen-thawed blastocysts from zygotes with no or one pronucleus for in vitro fertilization and intracytoplasmic sperm injection cycles.Archives of gynecology and obstetrics · 2023Article
- Effect of BMI on blood value of patients on HCG day with IUI treatment.BMC women's health · 2020Article
- The curious case of premature luteinization.Journal of assisted reproduction and genetics · 2018Review
- Serum progesterone trend after day of transfer predicts live birth in fresh IVF cycles.Journal of assisted reproduction and genetics · 2017Article
- Slow freezing should not be totally substituted by vitrification when applied to day 3 embryo cryopreservation: an analysis of 5613 frozen cycles.Journal of assisted reproduction and genetics · 2015Article
- Premature Progesterone Elevation inJournal of human reproductive sciencesArticle
- Comparative Study of Serum Progesterone Levels at the Time of Human Chorionic Gonadotropin Trigger and Ovum PickUp in Predicting Outcome in FreshJournal of human reproductive sciencesArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe study was designed to evaluate the relationship between serum progesterone (P4) response after hCG administration and the number of oocytes retrieved and the embryo quality in fresh IVF cycles.
methodsWe conducted a retrospective cohort study of women aged 24-43 years who underwent first fresh IVF cycle from 2011 to 2013 at a single practice. We compared the post-hCG serum P4 level with values on the day of hCG trigger. Patients were analyzed in long and short protocols independently. In addition, patients were stratified by post-hCG P4 response. Number of oocytes retrieved and embryo quality were the primary outcomes of interest. Ordinary least square regression models and logistic regression analysis models were created to identify predictive factors associated with embryological outcomes while adjusting for potential confounders.
resultsAmong the 2,978 IVF cycles, 2,484 patients were in long protocols, and 494 patients were in short protocols. After adjusting for patient age, rFSH duration, and basal FSH levels, the associations between P4 response after hCG administration and number of oocytes retrieved (P < 0.001) remained statistically significant in both long and short protocols. Additionally, mature oocyte rate, fertilization rate, good quality embryo rate, pregnancy rate and implantation rate were not significantly associated with the P4 increase when adjusting for the same factors. However, pregnancy rate and implantation rate from frozen-thawed cycles increased gradually across the seven groups.
conclusionsPost-hCG P4 levels were positively associated with the number of oocytes retrieved, but did not affect oocyte or embryo quality. Our study suggests that the change in the post-hCG P4 level is another parameter that can be used by clinicians to assess the number of oocytes retrieved, and may further to estimate the pregnancy rate and live birth rate indirectly.
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