Evidence map›Paper›PMID 25012772›Full record

ArticleInternational journal of obesity (2005)2014

Infant antibiotic exposure and the development of childhood overweight and central adiposity.

M B Azad, S L Bridgman, A B Becker, A L Kozyrskyj

Abstract read
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In one paragraph

Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 1 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

152 citing papers in PubMed, 1 synthesis or guideline pooled it, 324 citations in OpenAlex.

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  5. Gut Bacterial Diversity and Growth among Preschool Children in Burkina Faso.The American journal of tropical medicine and hygiene · 2020
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  8. Gut Microbial Diversity in Antibiotic-Naive Children After Systemic Antibiotic Exposure: A Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
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92 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M B Azad1] Pediatrics, University of Alberta, Edmonton, Alberta, Canada [2] Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada [3] Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
S L BridgmanPediatrics, University of Alberta, Edmonton, Alberta, Canada.
A B Becker1] Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada [2] Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
A L Kozyrskyj1] Pediatrics, University of Alberta, Edmonton, Alberta, Canada [2] School of Public Health, University of Alberta, Edmonton, Alberta, Canada [3] Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
University of Alberta · CAUniversity of Manitoba · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

backgroundObesity has been associated with disruption of the gut microbiota, which is established during infancy and vulnerable to disruption by antibiotics.

objectivesTo investigate the association between early-life antibiotic exposure and subsequent development of overweight and central adiposity.

methodsProvincial health-care records were linked to clinical and survey data from a Canadian longitudinal birth cohort study. Antibiotic exposure during the first year of life was documented from prescription records. Overweight and central adiposity were determined from anthropometric measurements at ages 9 (n=616) and 12 (n=431). Associations were determined by multiple logistic regression.

resultsInfants receiving antibiotics in the first year of life were more likely to be overweight later in childhood compared with those who were unexposed (32.4 versus 18.2% at age 12, P=0.002). Following adjustment for birth weight, breastfeeding, maternal overweight and other potential confounders, this association persisted in boys (aOR 5.35, 95% confidence interval (CI) 1.94-14.72) but not in girls (aOR 1.13, CI 0.46-2.81). Similar gender-specific associations were found for overweight at age 9 (aOR 2.19, CI 1.06-4.54 for boys; aOR 1.20, CI 0.53-2.70 for girls) and for high central adiposity at age 12 (aOR 2.85, CI 1.24-6.51 for boys; aOR 1.59, CI 0.68-3.68 for girls).

conclusionsAmong boys, antibiotic exposure during the first year of life was associated with an increased risk of overweight and central adiposity in preadolescence, indicating that antibiotic stewardship is particularly important during infancy. Given the current epidemic of childhood obesity and the high prevalence of infant antibiotic exposure, further studies are necessary to determine the mechanisms underlying this association, to identify the long-term health consequences, and to develop strategies for mitigating these effects when antibiotic exposure cannot be avoided.

Indexed as

Age of OnsetAnti-Bacterial AgentsBody Mass IndexCanadaChildChild, PreschoolCohort StudiesEnvironmental ExposureFemaleHumansInfantInfant, NewbornLongitudinal StudiesMaleMicrobiotaObesity, AbdominalAnti-Bacterial Agents

Identifiers

PMID25012772
OpenAlexW2033001504

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.