ArticleBMC pediatrics2014
Increased risk of major depression subsequent to a first-attack and non-infection caused urticaria in adolescence: a nationwide population-based study.
Article in BMC pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Psychiatric comorbidities in children and adolescents with chronic urticaria.World journal of pediatrics : WJP · 2023Pooled it
- Management of chronic urticaria in children: a clinical guideline.Italian journal of pediatrics · 2019Guideline
- Demographics and Clinical Features of Postresuscitation Comorbidities in Long-Term Survivors of Out-of-Hospital Cardiac Arrest: A National Follow-Up Study.BioMed research international · 2017Trial
- Biopsychosocial Insights on Adolescents With Chronic Urticaria: The Role of Eosinophils and Stress Coping Strategies.Clinical and translational allergy · 2025Article
- Genetic Insights Into Skin Diseases and Depression: Evidence From East Asian Mendelian Randomization Analysis.Alpha psychiatry · 2025Article
- Comorbidities of Chronic Urticaria: A glimpse into a complex relationship.Frontiers in allergy · 2022Review
- Prevalence and patient-reported outcomes of noncommunicable skin diseases among college students in China.JAAD international · 2020Article
- Psychiatric comorbidity in chronic urticaria patients: a systematic review and meta-analysis.Clinical and translational allergy · 2019Review
- Sense of coherence as a protective factor in chronic urticaria.Postepy dermatologii i alergologii · 2017Article
- [Dermatological diseases and their importance for psychiatry].Der Nervenarzt · 2017Review
- Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-infection caused urticaria is a common ailment in adolescents. Its symptoms (e.g., unusual rash appearance, limitation of daily activities, and recurrent itching) may contribute to the development of depressive stress in adolescents; the potential link has not been well studied. This study aimed to investigate the risk of major depression after a first-attack and non-infection caused urticaria.
methodsThis study used the Taiwan Longitudinal Health Insurance Database. A total of 5,755 adolescents hospitalized for a first-attack and non-infection caused urticaria from 2005 to 2009 were recruited as the study group, together with 17,265 matched non-urticarial enrollees who comprised the control group. Patients who had any history of urticaria or depression prior to the evaluation period were excluded. Each patient was followed for one year to identify the occurrence of depression. Cox proportional hazards models were generated to compute the risk of major depression, adjusting for the subjects' sociodemographic characteristics. Depression-free survival curves were also analyzed.
resultsThirty-four (0.6%) adolescents with non-infection caused urticaria and 59 (0.3%) non-urticarial control subjects suffered a new-onset episode of major depression during the study period. The stratified Cox proportional analysis showed that the crude hazard ratio (HR) of depression among adolescents with urticaria was 1.73 times (95% CI, 1.13-2.64) than that of the control subjects without urticaria. Moreover, the HR were higher in physical (HR: 3.39, 95% CI 2.77-11.52) and allergy chronic urticaria (HR: 2.43, 95% CI 3.18-9.78).
conclusionIndividuals who have a non-infection caused urticaria during adolescence are at a higher risk of developing major depression.
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