ArticleDiagnostic pathology2014
Accumulation of connective tissue growth factor+ cells during the early phase of rat traumatic brain injury.
Article in Diagnostic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 33 citations in OpenAlex.
- Short-term neural and glial response to mild traumatic brain injury in the hippocampus.Biophysical journal · 2024Article
- Elevated reactive aggression in forebrain-specificJournal of cell communication and signaling · 2024Article
- Acute and Chronic Neural and Glial Response to Mild Traumatic Brain Injury in the Hippocampus.bioRxiv : the preprint server for biology · 2024Article
- CCN2-induced lymphangiogenesis is mediated by the integrin αvβ5-ERK pathway and regulated by DUSP6.Scientific reports · 2022Article
- Molecular laterality encodes stress susceptibility in the medial prefrontal cortex.Molecular brain · 2021Article
- Cellular infiltration in traumatic brain injury.Journal of neuroinflammation · 2020Review
- CTGF Triggers Rat Astrocyte Activation and Astrocyte-Mediated Inflammatory Response in Culture Conditions.Inflammation · 2019Article
- Connective Tissue Growth Factor Is a Novel Prodepressant.Biological psychiatry · 2018Article
- Effect of acupuncture on the TLR2/4-NF-κB signalling pathway in a rat model of traumatic brain injury.Acupuncture in medicine : journal of the British Medical Acupuncture Society · 2018Article
- Article
- Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish.Science (New York, N.Y.) · 2016Article
- Chronic sciatic nerve compression induces fibrosis in dorsal root ganglia.Molecular medicine reports · 2016Article
- Emerging Roles for the Immune System in Traumatic Brain Injury.Frontiers in immunology · 2016Review
- Role of Microvascular Disruption in Brain Damage from Traumatic Brain Injury.Comprehensive Physiology · 2015Review
- Distinct actions of ancestral vinclozolin and juvenile stress on neural gene expression in the male rat.Frontiers in genetics · 2015Article
- Article
- Transcriptional re-programming in rat central nervous system two weeks after burn trauma: the impact of nephrilin treatment on the expression of oxidative stress-related genes.Scars, burns & healingArticle
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlial scar formation is a common histopathological feature of traumatic brain injury (TBI). Astrogliosis and expression of transforming growth factor beta (TGF-β) are key components of scar formation and blood-brain barrier modulation. Connective tissue growth factor (CTGF) is considered a cytokine mediating the effects of TGF-β.
methodsHere, we studied the CTGF expression in an open-skull weight-drop-induced TBI, with a focus on the early phase, most amenable to therapy.
resultsIn normal rat brains of our study, CTGF+ cells were rarely observed. Significant parenchymal accumulation of CTGF+ non-neuron cells was observed 72 h post-TBI and increased continuously during the investigating time. We also observed that the accumulated CTGF+ non-neuron cells were mainly distributed in the perilesional areas and showed activated astrocyte phenotypes with typical stellate morphologic characteristics.
conclusionOur observations demonstrated the time-dependent and lesion-associated accumulation of cellular CTGF expression in TBI, suggesting a pathological role of CTGF in TBI. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3963462091241165.
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