ArticleJournal of the American Society for Mass Spectrometry2014
Determination of internal energy distributions of laser electrospray mass spectrometry using thermometer ions and other biomolecules.
Article in Journal of the American Society for Mass Spectrometry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Leaving Group Effects in a Series of Electrosprayed CJournal of the American Society for Mass Spectrometry · 2019Article
- Synthesis of tellurium nanosheet for use in matrix assisted laser desorption/ionization time-of-flight mass spectrometry of small molecules.Mikrochimica acta · 2018Article
- Quantification of Protein-Ligand Interactions by Laser Electrospray Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2018Article
- Assessment of Reproducibility of Laser Electrospray Mass Spectrometry using Electrospray Deposition of Analyte.Journal of the American Society for Mass Spectrometry · 2017Article
- Isolating Protein Charge State Reduction in Electrospray Droplets Using Femtosecond Laser Vaporization.Journal of the American Society for Mass Spectrometry · 2017Article
- Oxidative Ionization Under Certain Negative-Ion Mass Spectrometric Conditions.Journal of the American Society for Mass Spectrometry · 2017Article
- Comparison of Internal Energy Distributions of Ions Created by Electrospray Ionization and Laser Ablation-Liquid Vortex Capture/Electrospray Ionization.Journal of the American Society for Mass Spectrometry · 2015Article
- Internal energy deposition for low energy, femtosecond laser vaporization and nanospray post-ionization mass spectrometry using thermometer ions.Journal of the American Society for Mass Spectrometry · 2015Article
- Thermometer Ions, Internal Energies, and In-Source Fragmentation in Ambient Ionization.Mass spectrometry reviewsReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The internal energy distributions for dried and liquid samples that were vaporized with femtosecond duration laser pulses centered at 800 nm and postionized by electrospray ionization-mass spectrometry (LEMS) were measured and compared with conventional electrospray ionization mass spectrometry (ESI-MS). The internal energies of the mass spectral techniques were determined by plotting the ratio of the intact parent molecular features to all integrated ion intensities of the fragments as a function of collisional energy using benzylpyridinium salts and peptides. Measurements of dried p-substituted benzylpyridinium salts using LEMS resulted in a greater extent of fragmentation in addition to the benzyl cation. The mean relative internal energies, <E(int)> were determined to be 1.62 ± 0.06, 2.0 ± 0.5, and 1.6 ± 0.3 eV for ESI-MS, dried LEMS, and liquid LEMS studies, respectively. Two-photon resonances with the laser pulses likely caused lower survival yields in LEMS analyses of dried samples but not liquid samples. In studies with larger biomolecules, LEMS analyses of dried samples from glass showed a decrease in survival yield compared with conventional ESI-MS for leucine enkephalin and bradykinin of ~15% and 11%, respectively. The survival yields for liquid LEMS analyses were comparable to or better than ESI-MS for benzylpyridinium salts and large biomolecules.
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