ArticleJournal of affective disorders2014
Perinatal depression and omega-3 fatty acids: a Mendelian randomisation study.
Article in Journal of affective disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Current state of nutritional psychiatry: A scoping review of randomized controlled trials.World journal of methodology · 2025Article
- Effects of Dietary Fiber, Phenolic Compounds, and Fatty Acids on Mental Health: Possible Interactions with Genetic and Epigenetic Aspects.Nutrients · 2024Review
- Association of serum fatty acid pattern with depression in U.S. adults: analysis of NHANES 2011-2012.Lipids in health and disease · 2024Article
- Omega-3 fatty acids and major depression: a Mendelian randomization study.Translational psychiatry · 2024Article
- Bilirubin and postpartum depression: an observational and Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Mendelian randomization studies of depression: evidence, opportunities, and challenges.Annals of general psychiatry · 2023Review
- DHA supplementation and pregnancy complications.Journal of translational medicine · 2023Review
- Causal effects of fatty acids on depression: Mendelian randomization study.Frontiers in nutrition · 2022Article
- The Triad Mother-Breast Milk-Infant as Predictor of Future Health: A Narrative Review.Nutrients · 2021Review
- Postpartum Depression: Current Status and Possible Identification Using Biomarkers.Frontiers in psychiatry · 2021Review
- Mendelian randomisation for nutritional psychiatry.The lancet. Psychiatry · 2020Review
- Cigarette smoking and personality: interrogating causality using Mendelian randomisation.Psychological medicine · 2019Article
- A Birth Cohort Study on the Genetic Modification of the Association of Prenatal Methylmercury With Child Cognitive Development.American journal of epidemiology · 2019Article
- A role for vitamin D and omega-3 fatty acids in major depression? An exploration using genomics.Translational psychiatry · 2019Article
- Imbalance between Omega-6 and Omega-3 Polyunsaturated Fatty Acids in Early Pregnancy Is Predictive of Postpartum Depression in a Belgian Cohort.Nutrients · 2019Observational
- Arachidonic acid and colorectal adenoma risk: a Mendelian randomization study.Clinical epidemiology · 2019Article
- Serum n-3 polyunsaturated fatty acids are inversely associated with longitudinal changes in depressive symptoms during pregnancy.Epidemiology and psychiatric sciences · 2017Article
- Dietary n-3 Polyunsaturated Fatty Acids in Late Pregnancy and Postpartum Depressive Symptom among Japanese Women.Frontiers in psychiatry · 2017Article
- Maternal Diet and Nutrient Requirements in Pregnancy and Breastfeeding. An Italian Consensus Document.Nutrients · 2016Review
- Trans fatty acid intake is related to emotional affect in the Adventist Health Study-2.Nutrition research (New York, N.Y.) · 2016Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundThere have been numerous studies investigating the association between omega-3 fatty acids (FAs) and depression, with mixed findings. We propose an approach which is largely free from issues such as confounding or reverse causality, to investigate this relationship using observational data from a pregnancy cohort.
methodsThe Avon Longitudinal Study of Parents and Children (ALSPAC) cohort collected information on FA levels from antenatal blood samples and depressive symptoms at several time points during pregnancy and the postnatal period. Conventional epidemiological analyses were used in addition to a Mendelian randomisation (MR) approach to investigate the association between levels of two omega-3 FAs (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) and perinatal onset depression, antenatal depression (AND) and postnatal depression (PND).
resultsWeak evidence of a positive association with both EPA (OR=1.07; 95% CI: 0.99-1.15) and DHA (OR=1.08; 95% CI: 0.98-1.19) with perinatal onset depression was found using a multivariable logistic regression adjusting for social class and maternal age. However, the strength of association was found to attenuate when using an MR analysis to investigate DHA. LIMITATIONS: Pleiotropy is a potential limitation in MR analyses; we assume that the genetic variants included in the instrumental variable are associated only with our trait of interest (FAs) and thus cannot influence the outcome via any other pathway.
conclusionsWe found weak evidence of a positive association between omega-3 FAs and perinatal onset depression. However, without confirmation from the MR analysis, we are unable to draw conclusions regarding causality.
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