ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
IL-17 gene polymorphism is associated with susceptibility to gastric cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Variable roles of interleukin-17F in different cancers.BMC cancer · 2022Pooled it
- Genetic polymorphisms of IL-17A rs2275913, rs3748067 and IL-17F rs763780 in gastric cancer risk: evidence from 8124 cases and 9873 controls.Molecular biology reports · 2018Pooled it
- Associations of genotypes and haplotypes of IL-17 with risk of gastric cancer in an eastern Chinese population.Oncotarget · 2016Pooled it
- Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis.Scientific reports · 2016Pooled it
- Assessment of an onco-sexology support and follow-up program in cervical or vaginal cancer patients undergoing brachytherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Association Between the Interleukin-17 Gene Polymorphism -197G>A and the Risk of Prostate Cancer in a Galician Population.Pathology oncology research : POR · 2020Article
- Clinical efficacy of apatinib in treating metastatic gastric cancer and its effect on IL-17.Oncology letters · 2019Article
- CarcinogenicMolecular & cellular proteomics : MCP · 2019Article
- Association between IL-17A G197A polymorphism and gastric cancer risk: an updated meta-analysis based on 6,624 cases and 7,631 controls.OncoTargets and therapy · 2018Article
- IL-17 Gene Rs3748067 C>T Polymorphism and Gastric Cancer Risk: A Meta-analysis.Open life sciences · 2018Article
- IL-17 and colorectal cancer risk in the Middle East: gene polymorphisms and expression.Cancer management and research · 2018Article
- The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke.Oncotarget · 2017Article
- Interleukin-17A gene polymorphism is associated with susceptibility to gastric cancer.International journal of clinical and experimental pathology · 2015Article
- Association of interleukin-17 gene polymorphisms and Helicobacter pylori infection with gastric cancer susceptibility: a cumulative and comprehensive meta-analysis.International journal of clinical and experimental medicine · 2015Article
- IL-17A G197A gene polymorphism contributes to susceptibility for liver cirrhosis development from patients with chronic hepatitis B infection in Chinese population.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a case-control study to investigate the role of three common IL-17A and IL-17F single nucleotide polymorphisms (SNPs) on the susceptibility to gastric cancer. A case-control study was conducted using a Chinese study population of 462 gastric cancer subjects and 462 controls. Polymerase chain reaction restriction fragment length of polymorphism (PCR-RFLP) was taken to genotype rs2275913, rs763780, and rs3748067 within the IL-17 gene. When comparing demographic characteristics of gastric cancer between gastric cancer cases and control groups, cancer cases were more likely to be cigarette smokers and alcohol drinkers, have cancer history in the first relatives, and have higher infection rate of Helicobacter pylori. By conditional regression analysis, individuals carrying IL-17 rs2275913 GA, AA genotype, and A allele were associated with an increased gastric cancer risk. Those carrying rs3748067 CC genotype and C allele had a significantly increased risk for the development of gastric cancer. Moreover, rs2275913 and rs3748067 variations had association with cigarette smoking, alcohol drinking, and H. pylori infection on the risk of gastric cancer. These results suggest that rs2275913 and rs3748067 variations significantly increase gastric cancer risk in a Chinese population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.