ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Downregulation of tumor suppressor menin by miR-421 promotes proliferation and migration of neuroblastoma.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Role of non-coding RNAs in neuroblastoma.Cancer gene therapy · 2023Review
- Estimating the Prognosis of Low-Grade Glioma with Gene Attention Using Multi-Omics and Multi-Modal Schemes.Biology · 2022Article
- miR-421 promotes the viability of A549 lung cancer cells by targeting forkhead box O1.Oncology letters · 2020Article
- Long noncoding RNA MEG3 decreases the growth of head and neck squamous cell carcinoma by regulating the expression of miR-421 and E-cadherin.Cancer medicine · 2020Article
- ΜicroRNA‑421 participates in vitiligo development through regulating human melanocyte survival by targeting receptor‑interacting serine/threonine kinase 1.Molecular medicine reports · 2020Article
- LncRNA GATA6-AS inhibits cancer cell migration and invasion in gallbladder cancer by downregulating miR-421.OncoTargets and therapy · 2019Article
- Article
- Upregulated expression of miR-421 is associated with poor prognosis in non-small-cell lung cancer.Cancer management and research · 2018Article
- MiR-20a-5p suppresses tumor proliferation by targeting autophagy-related gene 7 in neuroblastoma.Cancer cell international · 2018Article
- miR-483-3p promotes proliferation and migration of neuroblastoma cells by targeting PUMA.International journal of clinical and experimental pathology · 2018Article
- Epigenetic regulation by the menin pathway.Endocrine-related cancer · 2017Review
- MicroRNA-421 promotes the proliferation and metastasis of gastric cancer cells by targeting claudin-11.Experimental and therapeutic medicine · 2017Article
- Article
- Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease.Oncotarget · 2016Article
- Circulating microRNAs and long non-coding RNAs in gastric cancer diagnosis: An update and review.World journal of gastroenterology · 2015Review
- Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells.BMC genomics · 2015Article
- MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine/threonine-protein kinase.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Modulation by miR-29b of intestinal epithelium homoeostasis through the repression of menin translation.The Biochemical journal · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroblastoma, featured by a high rate of spontaneous remissions, is the most common extra-cranial solid tumor in infants and children. Numerous reports have demonstrated that MicroRNAs (miRNAs) play essential roles in cancer progression, including cell proliferation, apoptosis, invasion, metastasis and angiogenesis. miR-421 functions as an onco-miR in some malignancies. However, its role in neuroblastoma remains poorly understood. In the present study, we found that miR-421 was increased in neuroblastoma tissues compared with matched adjacent normal tissues. Forced overexpression of miR-421 substantially enhanced cell proliferation, cell-cycle progression, migration, and invasion of neuroblastoma cells. At the molecular level, tumor suppressor menin was found to be a target of miR-421. Furthermore, downregulation of menin by small interfering RNA oligos exhibited similar effects with overexpression of miR-421. On the other hand, overexpression of menin partially reversed the proliferative effects of miR-421 in neuroblastoma cells. Collectively, miR-421 may promote neuroblastoma cell growth and motility partially by targeting menin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.