ArticleJournal of the American Society of Nephrology : JASN2014
Akt1-mediated fast/glycolytic skeletal muscle growth attenuates renal damage in experimental kidney disease.
Article in Journal of the American Society of Nephrology : JASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Pooled it
- Myokine SIRPα exacerbates kidney disease in diabetes.JCI insight · 2026Article
- Estimated potassium intake and the progression of chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Small Extracellular Vesicles Derived From Damaged Muscle Aggravate Kidney Injury Progression.Journal of cachexia, sarcopenia and muscle · 2025Article
- Associations of MRI-derived kidney volume, kidney function, body composition and physical performance in ≈38 000 UK Biobank participants: a population-based observational study.Clinical kidney journal · 2024Article
- Association of Lower Extremity Muscle Strength and Function with Renal Resistive Index in Individuals with and without Chronic Kidney Disease.Geriatrics (Basel, Switzerland) · 2023Article
- Trunk muscle quality and quantity are associated with renal volume in nondiabetic people.Clinical kidney journal · 2023Article
- Circulating non-coding RNAs in chronic kidney disease and its complications.Nature reviews. Nephrology · 2023Review
- Pathophysiological mechanisms leading to muscle loss in chronic kidney disease.Nature reviews. Nephrology · 2022Review
- Transcriptome profiles discriminate between Gram-positive and Gram-negative sepsis in preterm neonates.Pediatric research · 2022Observational
- Role of exosomes and exosomal microRNA in muscle-Kidney crosstalk in chronic kidney disease.Frontiers in cell and developmental biology · 2022Review
- A simple method of sarcopenia detection can predict adverse cardiovascular events in patients with abdominal obesity.International journal of obesity (2005) · 2021Article
- Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease.JCI insight · 2020Article
- Article
- Association of advanced glycation end products with sarcopenia and frailty in chronic kidney disease.Scientific reports · 2020Article
- Regular exercise and branched-chain amino acids prevent ischemic acute kidney injury-related muscle wasting in mice.Physiological reports · 2020Article
- Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis in Unilateral Ureteral Obstruction Mice.Human gene therapy · 2020Article
- Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats.Journal of diabetes research · 2020Article
- Transient Receptor Potential Channel 6 Knockout Ameliorates Kidney Fibrosis by Inhibition of Epithelial-Mesenchymal Transition.Frontiers in cell and developmental biology · 2020Article
- Deletion ofBioMed research international · 2020Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle wasting is frequently observed in patients with kidney disease, and low muscle strength is associated with poor outcomes in these patients. However, little is known about the effects of skeletal muscle growth per se on kidney diseases. In this study, we utilized a skeletal muscle-specific, inducible Akt1 transgenic (Akt1 TG) mouse model that promotes the growth of functional skeletal muscle independent of exercise to investigate the effects of muscle growth on kidney diseases. Seven days after Akt1 activation in skeletal muscle, renal injury was induced by unilateral ureteral obstruction (UUO) in Akt1 TG and wild-type (WT) control mice. The expression of atrogin-1, an atrophy-inducing gene in skeletal muscle, was upregulated 7 days after UUO in WT mice but not in Akt1 TG mice. UUO-induced renal interstitial fibrosis, tubular injury, apoptosis, and increased expression of inflammatory, fibrosis-related, and adhesion molecule genes were significantly diminished in Akt1 TG mice compared with WT mice. An increase in the activating phosphorylation of eNOS in the kidney accompanied the attenuation of renal damage by myogenic Akt1 activation. Treatment with the NOS inhibitor L-NAME abolished the protective effect of skeletal muscle Akt activation on obstructive kidney disease. In conclusion, Akt1-mediated muscle growth reduces renal damage in a model of obstructive kidney disease. This improvement appears to be mediated by an increase in eNOS signaling in the kidney. Our data support the concept that loss of muscle mass during kidney disease can contribute to renal failure, and maintaining muscle mass may improve clinical outcome.
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