Evidence map›Paper›PMID 25012147›Full record

ArticleSchizophrenia research2014

Current status specifiers for patients at clinical high risk for psychosis.

Scott W Woods, Barbara C Walsh, Jean Addington, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Robert Heinssen, Diana O Perkins, Larry J Seidman, Sarah I Tarbox and 3 more

Abstract readValidation Study
In one paragraph

Article in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Scott W WoodsDepartment of Psychiatry, Yale University, New Haven, CT, United States. Electronic address: scott.woods@yale.edu.
Barbara C WalshDepartment of Psychiatry, Yale University, New Haven, CT, United States.
Jean AddingtonDepartment of Psychiatry, University of Calgary, Calgary, Alberta, Canada.
Kristin S CadenheadDepartment of Psychiatry, UCSD, San Diego, CA, United States.
Tyrone D CannonDepartment of Psychology, Yale University, New Haven, CT, United States.
Barbara A CornblattDepartment of Psychiatry, Zucker Hillside Hospital, Long Island, NY, United States.
Robert HeinssenDivision of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD, United States.
Diana O PerkinsDepartment of Psychiatry, University of North Carolina, Chapel Hill, NC, United States.
Larry J SeidmanDepartment of Psychiatry, Harvard Medical School, Boston, MA, United States.
Sarah I TarboxDepartment of Psychiatry, Yale University, New Haven, CT, United States.
Ming T TsuangDepartment of Psychiatry, UCSD, San Diego, CA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.
Elaine F WalkerDepartments of Psychology and Psychiatry, Emory University, Atlanta, GA, United States.
Thomas H McGlashanDepartment of Psychiatry, Yale University, New Haven, CT, United States.

Funding

1/9 Predictors and Mechanisms of Conversion to PsychosisU01MH081902 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2008 to 2018
$12.4M
Vulnerability to Progression SchizophreniaP50MH080272 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WOO, TSUNGUNG · 2007 to 2011
$9.9M
5/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082004 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2008 to 2018
$7.5M
Administrative Supplement Harmonization of At Risk Multisite Observational Networks for Youth(HARMONY)U01MH081928 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI STONE, WILLIAM SETH · 2008 to 2018
$7.1M
4/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081857 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORNBLATT, BARBARA A. · 2008 to 2018
$6.2M
8/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082022 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 2008 to 2018
$6.0M
2/9 - Predictors and Mechanisms of Conversion to PsychosisU01MH081988 · NIMH · EMORY UNIVERSITY · PI WALKER, ELAINE FRAN · 2008 to 2018
$5.4M
6/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081944 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2008 to 2018
$4.9M
"7/9" Predictors and Mechanisms of Conversion to PsychosisU01MH081984 · NIMH · UNIVERSITY OF CALGARY · PI ADDINGTON, JEAN M · 2008 to 2018
$4.2M
VULNERABILITY MARKERS IN PRODROMAL SCHIZOPHRENIAR01MH060720 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2000 to 2010
$4.0M
CHARACTERIZATION OF PRODROMAL SCHIZOPHRENIAR01MH061523 · NIMH · LONG ISLAND JEWISH MEDICAL CENTER · PI CORNBLATT, BARBARA A. · 2000 to 2009
$3.6M
Working Memory and Social Functioning in SchizophreniaR01MH065079 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CANNON, TYRONE D · 2003 to 2007
$2.7M
NIMH NIH HHS K23 MH001905NIMH NIH HHS K24 MH076191NIMH NIH HHS K24 MH76191NIMH NIH HHS MH081902NIMH NIH HHS P50 MH080272NIMH NIH HHS P50MH080272NIMH NIH HHS R01 MH060720NIMH NIH HHS R01 MH061523NIMH NIH HHS R01 MH062066NIMH NIH HHS R01 MH065079NIMH NIH HHS R01 MH065562NIMH NIH HHS R01 MH60720NIMH NIH HHS U01 MH060720NIMH NIH HHS U01 MH061523NIMH NIH HHS U01 MH062066NIMH NIH HHS U01 MH065079NIMH NIH HHS U01 MH065562NIMH NIH HHS U01 MH066069NIMH NIH HHS U01 MH066134NIMH NIH HHS U01 MH066160NIMH NIH HHS U01MH066160NIMH NIH HHS U01 MH081857NIMH NIH HHS U01 MH081902NIMH NIH HHS U01 MH081928NIMH NIH HHS U01 MH081944NIMH NIH HHS U01 MH081984NIMH NIH HHS U01MH081984NIMH NIH HHS U01 MH081988NIMH NIH HHS U01 MH082004NIMH NIH HHS U01 MH082022
6 · The paper itself

Abstract

backgroundLongitudinal studies of the clinical high risk (CHR) syndrome for psychosis have emphasized the conversion vs non-conversion distinction and thus far have not focused intensively on classification among non-converters. The present study proposes a system for classifying CHR outcomes over time when using the Structured Interview for Psychosis-risk Syndromes and evaluates its validity.

methodThe system for classifying CHR outcomes is referred to as "current status specifiers," with "current" meaning over the month prior to the present evaluation and "specifiers" indicating a set of labels and descriptions of the statuses. Specifiers for four current statuses are described: progression, persistence, partial remission, and full remission. Data from the North American Prodromal Longitudinal Study were employed to test convergent, discriminant, and predictive validity of the current status distinctions.

resultsValidity analyses partly supported current status distinctions. Social and role functioning were more impaired in progressive and persistent than in remitted patients, suggesting a degree of convergent validity. Agreement between CHR current statuses and current statuses for a different diagnostic construct (DSM-IV Major Depression) was poor, suggesting discriminant validity. The proportion converting to psychosis within a year was significantly higher in cases meeting progression criteria than in those meeting persistence criteria and tended to be higher than in those meeting full remission criteria, consistent with a degree of predictive validity. DISCUSSION: CHR syndrome current status specifiers could offer a potentially valid and useful description of current clinical status among non-converters. Study in additional samples is needed.

Indexed as

Interview, PsychologicalDisease ProgressionHumansLongitudinal StudiesPsychotic DisordersRiskClinical high riskCourse of illnessCurrent statusPsychosisRisk syndrome

Identifiers

PMID25012147
PMCPMC4152558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.