Evidence map›Paper›PMID 25012076›Full record

ArticleJournal of electrocardiology

Repolarization lability measured on 10-second ECG by spatial TT' angle: reproducibility and agreement with QT variability.

Albert Feeny, Lichy Han, Larisa G Tereshchenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of electrocardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Heart Rate Influence on the QT Variability Risk Factors.Diagnostics (Basel, Switzerland) · 2020
    Article
  4. Article
  5. QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2016
    Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Albert FeenyWhiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Lichy HanWhiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Larisa G TereshchenkoThe Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD, USA; The Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address: tereshch@ohsu.edu.

Funding

Novel ECG Measures and Risk of Sudden Cardiac DeathR01HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2013 to 2016
$1.5M
NHLBI NIH HHS 1R01HL118277-01A1NHLBI NIH HHS R01 HL118277
6 · The paper itself

Abstract

backgroundReproducibility of spatial TT' angle on the 10-second ECG and its agreement with QT variability has not been previously studied.

methodsWe analyzed 2 randomly selected 10-second segments within 3-minute resting orthogonal ECG in 172 healthy IDEAL study participants (age 38.1±15.2years, 50% male, 94% white). Repolarization lability was measured by the QT variance (QTV), short-term QT variability (STV(QT)), and spatial TT' angle. Bland-Altman analysis was used to assess the agreement between different log-transformed metrics of repolarization lability, and to assess the reproducibility.

resultsThe heart rate showed a very high reproducibility (bias 0.14%, Lin's rho_c=0.99). As expected, noise suppression by averaging improves reproducibility. Agreement between two 10-second LogQTV was poor (bias -0.04; 95% limits of agreement [-1.89; 1.81]), while LogSTV(QT) (0.04 [-1.01; 1.10]), and especially LogTT' angle (-0.009 [-0.84; 0.82]) was better.

conclusionTT' angle is a satisfactory reproducible metric of repolarization lability on the 10-second ECG.

Indexed as

AdultElectrocardiographyFemaleHeart Conduction SystemHeart RateHumansMaleReproducibility of ResultsECGRepolarizationSpatial TT′ angle

Identifiers

PMID25012076
PMCPMC4143436

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.