SynthesisBMJ open2014
Predictors of hospitalisations for heart failure and mortality in patients with pulmonary hypertension associated with left heart disease: a systematic review.
Synthesis in BMJ open, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Doppler trans-thoracic echocardiography for detection of pulmonary hypertension in adults.The Cochrane database of systematic reviews · 2022Pooled it
- Prevalence and etiologies of pulmonary hypertension in Africa: a systematic review and meta-analysis.BMC pulmonary medicine · 2017Pooled it
- Pulmonary hypertension.Nature reviews. Disease primers · 2024Review
- Myeloid Cell Derived IL1β Contributes to Pulmonary Hypertension in HFpEF.Circulation research · 2023Article
- Persistence of pulmonary hypertension in patients undergoing ventricular assist devices and orthotopic heart transplantation.Pulmonary circulation · 2023Article
- HIV status and survival of patients with pulmonary hypertension due to left heart disease: the Pan African Pulmonary Hypertension Cohort.Scientific reports · 2023Article
- Long-Term Follow-up of Human Immunodeficiency Virus-Associated Pulmonary Hypertension: Clinical Features and Survival Outcomes of the Pan Africa Pulmonary Hypertension Cohort (PAPUCO).Open forum infectious diseases · 2022Article
- Animal models of pulmonary hypertension due to left heart disease.Animal models and experimental medicine · 2022Review
- Understanding the Pathobiology of Pulmonary Hypertension Due to Left Heart Disease.Circulation research · 2022Review
- Epidemiology and outcomes of pulmonary hypertension in the cardiac intensive care unit.European heart journal. Acute cardiovascular care · 2022Article
- Left atrial unloading with an 8 mm septal cutting balloon to treat postcapillary pulmonary hypertension: a case report.ESC heart failure · 2022Article
- Pulmonary hypertension among patients hospitalized with acute heart failure in Buea, South West Region of Cameroon.The Pan African medical journal · 2022Article
- Increased myocardial oxygen consumption rates are associated with maladaptive right ventricular remodeling and decreased event-free survival in heart failure patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- A predictive model for dilated cardiomyopathy with pulmonary hypertension.ESC heart failure · 2021Article
- Exercise intolerance in heart failure: The important role of pulmonary hypertension.Experimental physiology · 2020Review
- Retrospective single center cohort study: effect of intensive home hemodialysis on right ventricular systolic pressure and clinical outcomes.BMC nephrology · 2020Article
- Pulmonary hypertension in low- and middle-income countries with focus on sub-Saharan Africa.Cardiovascular diagnosis and therapy · 2020Review
- Polymyositis/dermatomyositis is a potential risk factor for acute respiratory failure: a pulmonary heart disease.Annals of translational medicine · 2020Article
- Healthcare utilization, medical expenditure, and mortality in Korean patients with pulmonary hypertension.BMC pulmonary medicine · 2019Article
- Pulmonary hypertension due to left heart disease: diagnostic and prognostic value of CT in chronic systolic heart failure.European radiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesLeft heart disease (LHD) is the main cause of pulmonary hypertension (PH), but little is known regarding the predictors of adverse outcome of PH associated with LHD (PH-LHD). We conducted a systematic review to investigate the predictors of hospitalisations for heart failure and mortality in patients with PH-LHD.
designSystematic review. DATA SOURCES: PubMed MEDLINE and SCOPUS from inception to August 2013 were searched, and citations identified via the ISI Web of Science. STUDY SELECTION: Studies that reported on hospitalisation and/or mortality in patients with PH-LHD were included if the age of participants was greater than 18 years and PH was diagnosed using Doppler echocardiography and/or right heart catheterisation. Two reviewers independently selected studies, assessed their quality and extracted relevant data.
resultsIn all, 45 studies (38 from Europe and USA) were included among which 71.1% were of high quality. 39 studies were published between 2003 and 2013. The number of participants across studies ranged from 46 to 2385; the proportion of men from 21% to 91%; mean/median age from 63 to 82 years; and prevalence of PH from 7% to 83.3%. PH was consistently associated with increased mortality risk in all forms of LHD, except for aortic valve disease where findings were inconsistent. Six of the nine studies with data available on hospitalisations reported a significant adverse effect of PH on hospitalisation risk. Other predictors of adverse outcome were very broad and heterogeneous including right ventricular dysfunction, functional class, left ventricular function and presence of kidney disease.
conclusionsPH is almost invariably associated with increased mortality risk in patients with LHD. However, effects on hospitalisation risk are yet to be fully characterised; while available evidence on the adverse effects of PH have been derived essentially from Caucasians.
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Registered trials
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