Evidence map›Paper›PMID 25011544›Full record

Trial reportScientific reports2014

Long-lasting changes in brain activation induced by a single REAC technology pulse in Wi-Fi bands. Randomized double-blind fMRI qualitative study.

Salvatore Rinaldi, Marco Mura, Alessandro Castagna, Vania Fontani

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07373366 (Effects of Neurobiological Therapy With Asymmetric Radio-electric Conveyer), which is not on this map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07373366 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Neurobiological Therapy With Asymmetric Radio-electric Conveyer (REAC) in Diffuse Axonal Injury: a Randomized Controlled Trial.

TypeinterventionalSponsorUniversity of Sao PauloRan2025 to 2027Enrolled60ConditionsTraumatic Brain InjuryArmsSubjects in the intervention group receive low-frequency radioelectric therapy, Sham, the device simulates a therapy session
3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Salvatore Rinaldi1] Department of regenerative medicine, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy [2] Department of neuro psycho physical optimization, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy.
Marco MuraInstitute of Radiology, University of Cagliari, 09042 Monserrato, Italy.
Alessandro Castagna1] Department of regenerative medicine, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy [2] Department of neuro psycho physical optimization, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy.
Vania Fontani1] Department of regenerative medicine, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy [2] Department of neuro psycho physical optimization, Rinaldi Fontani Institute, Viale Belfiore 43, 50144 Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this randomized double-blind study was to evaluate in healthy adult subjects, with functional magnetic resonance imaging (fMRI), long lasting changes in brain activation patterns following administration of a single, 250 milliseconds pulse emitted with radio-electric asymmetric conveyer (REAC) technology in the Wi-Fi bands. The REAC impulse was not administered during the scan, but after this, according to a protocol that has previously been demonstrated to be effective in improving motor control and postural balance, in healthy subjects and patients. The study was conducted on 33 healthy volunteers, performed with a 1.5 T unit while operating a motor block task involving cyclical and alternating flexion and extension of one leg. Subsequently subjects were randomly divided into a treatment and a sham treatment control group. Repeated fMRI examinations were performed following the administration of the REAC pulse or sham treatment. The Treated group showed cerebellar and ponto-mesencephalic activation components that disappeared in the second scan, while these activation components persisted in the Sham group. This study shows that a very weak signal, such as 250 milliseconds Wi-Fi pulse, administered with REAC technology, could lead to lasting effects on brain activity modification.

Indexed as

AdultBrainDouble-Blind MethodElectricityFemaleHumansInternetMagnetic Resonance ImagingMaleMiddle AgedMotor ActivityRadio WavesYoung Adult

Identifiers

PMID25011544
PMCPMC4092330

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.