ArticleBiology direct2014
Translational selection in human: more pronounced in housekeeping genes.
Article in Biology direct, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
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- Comprehensive Analysis of Ubiquitously Expressed Genes in Humans from A Data-driven Perspective.Genomics, proteomics & bioinformatics · 2023Article
- Comparative chloroplast genome and phylogenetic analyses of Chinese Polyspora.Scientific reports · 2022Article
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- Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome.Journal of molecular evolution · 2020Article
- The comprehensive detection of miRNA, lncRNA, and circRNA in regulation of mouse melanocyte and skin development.Biological research · 2020Article
- Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes.Frontiers in physiology · 2018Article
- Adenine Enrichment at the Fourth CDS Residue in Bacterial Genes Is Consistent with Error Proofing for +1 Frameshifts.Molecular biology and evolution · 2017Article
- Co-adaption of tRNA gene copy number and amino acid usage influences translation rates in three life domains.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- A benchmark of gene expression tissue-specificity metrics.Briefings in bioinformatics · 2017Article
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- Modeling the dynamics of chromosomal alteration progression in cervical cancer: A computational model.PloS one · 2017Article
- Both Male-Biased and Female-Biased Genes Evolve Faster in Fish Genomes.Genome biology and evolution · 2016Article
- Tissue Specific Expression Levels of Apoptosis Involved Genes Have Correlations with Codon and Amino Acid Usage.Genomics & informatics · 2016Article
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Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranslational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular eukaryotes. Recent evidence has shown that translational selection is weakly operative in highly expressed genes in human and other vertebrates. However, it remains unclear whether translational selection acts differentially on human genes depending on their expression patterns.
resultsHere we report that human housekeeping (HK) genes that are strictly defined as genes that are expressed ubiquitously and consistently in most or all tissues, are under stronger translational selection.
conclusionsThese observations clearly show that translational selection is also closely associated with expression pattern. Our results suggest that human HK genes are more efficiently and/or accurately translated into proteins, which will inevitably open up a new understanding of HK genes and the regulation of gene expression. REVIEWERS: This article was reviewed by Yuan Yuan, Baylor College of Medicine; Han Liang, University of Texas MD Anderson Cancer Center (nominated by Dr Laura Landweber) Eugene Koonin, NCBI, NLM, NIH, United States of America Sandor Pongor, International Centre for Genetic Engineering and biotechnology (ICGEB), Italy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.