ArticleRadiation oncology (London, England)2014
A treatment planning study comparing Elekta VMAT and fixed field IMRT using the varian treatment planning system eclipse.
Article in Radiation oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
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- Assessment of efficacy in automated plan generation for Varian Ethos intelligent optimization engine.Journal of applied clinical medical physics · 2022Article
- Dosimetric and radiobiological comparison of simultaneous integrated boost radiotherapy for early stage right side breast cancer between three techniques: IMRT, hybrid IMRT and hybrid VMAT.Radiation oncology (London, England) · 2022Article
- Half-beam volumetric-modulated arc therapy in adjuvant radiotherapy for gynecological cancers.Journal of applied clinical medical physics · 2022Article
- Impact of adjuvant radiotherapy on the survival of women with optimally resected stage III endometrial cancer in the era of modern radiotherapy: a retrospective study.Radiation oncology (London, England) · 2020Article
- Dosimetric comparisons of craniospinal axis irradiation using helical tomotherapy, volume-modulated arc therapy and intensity-modulated radiotherapy for medulloblastoma.Translational cancer research · 2019Article
- Comparison of dose metrics between automated and manual radiotherapy planning for advanced stage non-small cell lung cancer with volumetric modulated arc therapy.Physics and imaging in radiation oncology · 2019Article
- Estimation of radiotherapy modalities for patients with stage I-II nasal natural killer T-Cell lymphoma.Cancer management and research · 2019Article
- Dosimetric comparison of helical tomotherapy, VMAT, fixed-field IMRT and 3D-conformal radiotherapy for stage I-II nasal natural killer T-cell lymphoma.Radiation oncology (London, England) · 2017Article
- Impact of MLC properties and IMRT technique in meningioma and head-and-neck treatments.Radiation oncology (London, England) · 2015Article
- Comparison of breast simultaneous integrated boost (SIB) radiotherapy techniques.Radiation oncology (London, England) · 2015Article
- Intensity-modulated radiotherapy and volumetric-modulated arc therapy have distinct clinical advantages in non-small cell lung cancer treatment.Medical oncology (Northwood, London, England) · 2015Article
- mARC vs. IMRT radiotherapy of the prostate with flat and flattening-filter-free beam energies.Radiation oncology (London, England) · 2014Article
- Dosimetric Comparison of SequentialIn vivo (Athens, Greece)Article
- Evaluation of Dosimetric Efficacy of RapidArc and Intensity-modulated Radiation Therapy Techniques in Head-and-Neck Cancers.Journal of medical physicsArticle
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe newest release of the Eclipse (Varian) treatment planning system (TPS) includes an optimizing engine for Elekta volumetric-modulated arc therapy (VMAT) planning. The purpose of this study was to evaluate this new algorithm and to compare it to intensity-modulated radiation therapy (IMRT) for various disease sites by creating single- and double-arc VMAT plans.
methodsA total of 162 plans were evaluated in this study, including 38 endometrial, 57 head and neck, 12 brain, 10 breast and 45 prostate cancer cases. The real-life IMRT plans were developed during routine clinical cases using the TPS Eclipse. VMAT plans were generated using a preclinical version of Eclipse with tumor-region-specific optimizing templates without interference of the operator: with one full arc (1A) and with two full arcs (2A), and with partial arcs for breast and prostate with hip implant cases. All plans were evaluated based on target coverage, homogeneity and conformity. The organs at risk (OARs) were analyzed according to plan objectives, such as the mean and maximum doses. If one or more objectives were exceeded, the plan was considered clinically unacceptable, and a second VMAT plan was created by adapting the optimization penalties once.
resultsCompared to IMRT, single- and double-arc VMAT plans showed comparable or better results concerning the target coverage: the maximum dose in the target for 1A is the same as that for IMRT; for 2A, an average reduction of 1.3% over all plans was observed. The conformity showed a statistically significant improvement for both 1A (+3%) and 2A (+6%). The mean total body dose was statistically significant lower for the considered arc techniques (IMRT: 16.0 Gy, VMAT: 15.3 Gy, p < 0.001). However, the sparing of OARs shows individual behavior that depends strongly on the different tumor regions. A clear difference is found in the number of monitor units (MUs) per plan: VMAT shows a reduction of 31%.
conclusionThese findings demonstrate that based on optimizing templates with minimal interaction of the operator, the Eclipse TPS is able to achieve a plan quality for the Elekta VMAT delivery technique that is comparable to that of fixed-field IMRT. Plans with two arcs show better dose distributions than plans with one arc.
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