Evidence map›Paper›PMID 25011450›Full record

SynthesisBMJ (Clinical research ed.)2014

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.

Michael V Holmes, Caroline E Dale, Luisa Zuccolo, Richard J Silverwood, Yiran Guo, Zheng Ye, David Prieto-Merino, Abbas Dehghan, Stella Trompet, Andrew Wong and 146 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 297 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
297citing papers in PubMed, 14 pooled it
49.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

297 citing papers in PubMed, 14 syntheses or guidelines pooled it, 671 citations in OpenAlex.

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  20. Effect ofBJPsych open · 2026
    Article

237 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

156 authors at 20 institutions in 16 countries.

Michael V HolmesGenetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Caroline E DaleFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Luisa ZuccoloMRC Integrative Epidemiology Unit (IEU) at the Universty of Bristol, Oakfield House, Bristol BS8 2BN, UK.
Richard J SilverwoodFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK Centre for Statistical Methodology, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Yiran GuoCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China.
Zheng YeMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
David Prieto-MerinoFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Abbas DehghanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, the Netherlands.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Alana CavadinoCentre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK.
Dagmar DroganGerman Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Shanshan LiDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA Juan-P.Casas@lshtm.ac.uk.
Ajay YesupriyaOffice of Public Health Genomics, Office of Epidemiology, Surveillance, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Maarten LeusinkDivision of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Johan SundstromDepartment of Medical Sciences, Uppsala University, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.
Jaroslav A HubacekCenter for Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 4, 14021, Czech Republic.
Hynek PikhartDepartment of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
Daniel I SwerdlowGenetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK.
Andrie G PanayiotouCyprus International Institute for Environmental and Public Health in association with the Harvard School of Public Health, Cyprus University of Technology, 3603 Limassol, Cyprus.
Svetlana A BorinskayaVavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Chris FinanGenetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK.
Sonia ShahUCL Genetics Institute, Department of Genetics Environment and Evolution, London, WC1E 6BT, UK.
Karoline B KuchenbaeckerCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Tina ShahGenetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK.
Jorgen EngmannGenetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK.
Lasse FolkersenAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Per ErikssonAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
Fulvio RicceriUnit of Cancer Epidemiology, San Giovanni Battista Hospital and Center for Cancer Prevention (CPO-Piemonte), 10129, Torino, Italy.
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Carlotta SacerdoteUnit of Cancer Epidemiology, San Giovanni Battista Hospital and Center for Cancer Prevention (CPO-Piemonte), 10129, Torino, Italy.
Dale M GambleMayo Clinic Department of Neurology, Jacksonville, FL 32224, USA.
Sruti RayaproluDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA.
Owen A RossDepartment of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA.
Stela McLachlanCentre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK.
Olga VikhirevaDepartment of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
Ivonne SluijsJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Vera AdamkovaDepartment of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Prague 4, 14021, Czech Republic.
Leon FlickerWestern Australian Centre for Health & Ageing, Centre for Medical Research, University of Western Australia, Perth, Australia.
Frank M van BockxmeerDepartment of Clinical Biochemistry, Royal Perth Hospital and School of Surgery, the University of Western Australia.
Christine PowerCentre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK.
Pedro Marques-VidalDepartment of Internal Medicine, Internal Medicine, CHUV, Lausanne, Switzerland.
Tom MeadeFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Michael G MarmotUCL Institute of Health Equity, Department of Epidemiology & Public Health, London WC1E 7HB, UK.
Jose M FerroInstituto Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, 1649-028 Lisbon, Portugal Servico Neurologia, Hospital de Santa Maria, 1649-035 Lisbon, Portugal.
Sofia Paulos-PinheiroInstituto Nacional de Saude Doutor Ricardo Jorge, 1649-016 Lisbon, Portugal Faculdade Ciencias Universidade Lisboa, 1749-016 Lisbon, Portugal.
Steve E HumphriesCentre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
Philippa J TalmudCentre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
Irene Mateo LeachDepartment of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
Allan LinnebergResearch Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark.
Tea SkaabyResearch Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark.
Pieter A DoevendansDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Maarten J CramerDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
Pim van der HarstDepartment of Cardiology, University Medical Center Groningen, Groningen, The Netherlands Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.
Olaf H KlungelDivision of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Nicole F DowlingOffice of Public Health Genomics, Office of Epidemiology, Surveillance, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Anna F DominiczakInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Meena KumariGenetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK.
Andrew N NicolaidesVascular Screening and Diagnostic Centre, Ayios Dometios, Nicosia, Cyprus Deparment of Vascular Surgery, Imperial College, London, SW7 2BX, UK Cyprus Cardiovascular Disease Educational and Research trust, Nicosia, Cyprus.
Cornelia WeikertGerman Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Heiner BoeingGerman Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Shah EbrahimFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Tom R GauntMRC Integrative Epidemiology Unit (IEU) at the Universty of Bristol, Oakfield House, Bristol BS8 2BN, UK.
Jackie F PriceCentre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK.
Lars LannfeltDepartment of Public Health & Caring Sciences, Uppsala University, Uppsala University Hospital, SE-75185 Uppsala, Sweden.
Anne PeaseyDepartment of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
Ruzena KubinovaCentre for Health Monitoring, National Institute of Public Health, 100 42 Prague, Czech Republic.
Andrzej PajakDepartment of Epidemiology and Population Studies, Institute of Public Health, Jagiellonian University Medical College, 31-531 Krakow, Poland.
Sofia MalyutinaInstitute of Internal and Preventative Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia, 630089 Dept of Internal Medicine, Novosibirsk State Medical University, Novosibirsk, Russia, 630091.
Mikhail I VoevodaInstitute of Internal and Preventative Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia, 630089 Faculty of Medicine, Novosibirsk State University, Novosibirsk, Russia, 630090.
Abdonas TamosiunasDepartment of Population Studies, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania.
Anke H Maitland-van der ZeeDivision of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
Paul E NormanSchool of Surgery, University of Western Australia, Perth, Australia.
Graeme J HankeyDepartment of Neurology, Sir Charles Gairdner Hospital, Perth, Australia School of Medicine and Pharmacology, The University of Western Australia, Nedlands, Perth, Australia.
Manuela M BergmannGerman Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Jackie CooperCentre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK WC1E 6JF.
Jutta PalmenCentre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
Wilko SpieringDepartment of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Pim A de JongDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Diana KuhMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Rebecca HardyMRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Andre G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Ian FordRobertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
Elina HyppönenCentre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK School of Population Health and Sansom Institute for Health Research, University of South Australia, Adelaide SA 5000, Australia South Australian Health and Medical Research Institute, Adelaide SA5000, Australia.
Osvaldo P AlmeidaWestern Australian Centre for Health & Ageing, Centre for Medical Research, University of Western Australia, Perth, Australia School of Psychiatry & Clinical Neurosciences (M573), University of Western Australia, Perth 6009, Australia Department of Psychiatry, Royal Perth Hospital, Perth, Australia.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Kay-Tee KhawDepartment of Primary Care and Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Anders HamstenAtherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
Lise Lotte N HusemoenResearch Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark.
Anne TjønnelandDanish Cancer Society, Strandboulevarden, Copenhagen, Denmark.
Janne S TolstrupNational Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Eric RimmDepartment of Epidemiology and Department of Nutrition, Harvard School of Public Health, Boston, MA, USA Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Joline W J BeulensJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.
W M Monique VerschurenNational Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
N Charlotte Onland-MoretJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.
Marten H HofkerDept Pathology and Medical Biology, Medical Biology division, Molecular Genetics, University Medical Center Groningen and Groningen University, Groningen, The Netherlands.
S Goya WannametheeDepartment of Primary Care & Population Health, UCL, London, UK.
Peter H WhincupPopulation Health Research Institute, St George's, University of London, London, UK.
Richard MorrisDepartment of Primary Care & Population Health, UCL, London, UK.
Astrid M VicenteInstituto Nacional de Saude Doutor Ricardo Jorge, 1649-016 Lisbon, Portugal Instituto Gulbenkian Ciencia, P-2780-156 Oeiras, Portugal Biofig - Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, 1749-016 Lisboa, Portugal.
Hugh WatkinsWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.
Martin FarrallWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, the Netherlands.
James MeschiaMayo Clinic Department of Neurology, Jacksonville, FL 32224, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA National Heart, Lung, and Blood Institute's The Framingham Heart Study, Framingham, Massachusetts, USA.
Stephen J SharpMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Myriam FornageInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Texas, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Andrea Z LaCroixDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
James Y DaiDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Matthew B LanktreeDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada L8S4L8.
David S SiscovickNew York Academy of Medicine, New York, NY 10021, USA.
Eric JorgensonDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Bonnie SpringNorthwestern University, Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL, USA.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Yun R LiCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA Juan-P.Casas@lshtm.ac.uk.
Sarah G BuxbaumSchool of Health Sciences, Jackson State University, Jackson, MS, USA.
Pamela J SchreinerSchool of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
R Curtis EllisonPreventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, USA.
Sanjay R PatelDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital; Harvard Medical School, Boston USA Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham and Women's Hospital; Harvard Medical School, Boston USA.
Andrew D JohnsonNational Heart, Lung, and Blood Institute's The Framingham Heart Study, Framingham, Massachusetts, USA.
Ron C HoogeveenBaylor College of Medicine, Department of Medicine, Division of Atherosclerosis & Vascular Medicine, Houston, Texas 77030, USA.
Hakon HakonarsonCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, Calif, USA.
Eric BoerwinkleDivision of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Texas, USA.
Paul I W de BakkerJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
Mika KivimakiDepartment of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
Folkert W AsselbergsDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.
Naveed SattarBritish Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Debbie A LawlorMRC Integrative Epidemiology Unit (IEU) at the Universty of Bristol, Oakfield House, Bristol BS8 2BN, UK.
John WhittakerFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK Genetics, R&D, GlaxoSmithKline, Stevenage, UK.
George Davey SmithMRC Integrative Epidemiology Unit (IEU) at the Universty of Bristol, Oakfield House, Bristol BS8 2BN, UK.
Kenneth MukamalBeth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA,USA Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Leslie A LangeDepartment of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina 27514, USA.
Ajna HamidovicCollege of Pharmacy, The University of New Mexico, Albuquerque, NM, USA.
Aroon D HingoraniGenetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK.
Børge G NordestgaardThe Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark Faculty of Health Sciences, Copenhagen University Hospital, University of Copenhagen,Copenhagen, Denmark Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark.
Martin BobakDepartment of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
David A LeonFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
Tom M PalmerDivision of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
Alex P ReinerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Brendan J KeatingDepartment of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA.
Frank DudbridgeFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
Juan P CasasGenetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK Juan-P.Casas@lshtm.ac.uk.
InterAct Consortium
University College London · GBUniversity Medical Center Utrecht · NLLondon School of Hygiene & Tropical Medicine · GBErasmus MC · NLMRC Epidemiology Unit · GBUniversity of Western Australia · AUAddenbrooke's Hospital · GBFred Hutch Cancer Center · USGerman Institute of Human Nutrition · DEUniversity Medical Center Groningen · NLUniversity of Glasgow · GBBoston University · USCapital Region of Denmark · DKChildren's Hospital of Philadelphia · USUtrecht University · NLHarvard University · USInstitute of Clinical and Experimental Medicine · CZKarolinska Institutet · SELeiden University Medical Center · NLMayo Clinic in Florida · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Type 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
CANDIDATE GENE ASSOCIATION RESOURCE (CARE)N01HC65226 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2007 to 2009
$17.0M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
British Heart Foundation CH/98001British Heart Foundation PG/07/131/24254British Heart Foundation PG/09/022British Heart Foundation PG/13/66/30442British Heart Foundation PG/2008/008British Heart Foundation RG/07/005/23633British Heart Foundation RG/07/008/23674British Heart Foundation RG/08/008/25291British Heart Foundation RG/08/013/25942British Heart Foundation RG/10/12/28456British Heart Foundation RG/13/16/30528British Heart Foundation RG2008/014British Heart Foundation RG/98002Cancer Research UK 14136Department of Health 0090049Medical Research Council G0000934Medical Research Council G0100222Medical Research Council G0401527Medical Research Council G0600580Medical Research Council G0601647Medical Research Council G0601653Medical Research Council G0701830Medical Research Council G0701863Medical Research Council G0802432Medical Research Council G0902037Medical Research Council G0902144Medical Research Council G1000143Medical Research Council G1000616Medical Research Council G1000718Medical Research Council G1001799Medical Research Council G19/35Medical Research Council G8802774Medical Research Council MC_PC_15018Medical Research Council MC_U106179471Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/5Medical Research Council MC_UU_12013/8Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12019/1Medical Research Council MRC G0601653Medical Research Council MR/K006584/1Medical Research Council MR/K013351/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001079NCI NIH HHS CA55075NCI NIH HHS CA87969NCI NIH HHS P30 CA015704NCRR NIH HHS UL1RR025005NHGRI NIH HHS U01HG004402NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL080295NHLBI NIH HHS HL 114901NHLBI NIH HHS HL34594NHLBI NIH HHS HL35464NHLBI NIH HHS HL36310NHLBI NIH HHS HL46380NHLBI NIH HHS N01-HC-48047NHLBI NIH HHS N01-HC-48048NHLBI NIH HHS N01-HC-48049NHLBI NIH HHS N01-HC-48050NHLBI NIH HHS N01 HC55222NHLBI NIH HHS N01HC65226NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS N01-HC-95095NHLBI NIH HHS NIH HL075451NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL114901NHLBI NIH HHS R01HL59367NIAAA NIH HHS AA021223-01NIAAA NIH HHS AA11181NIAAA NIH HHS R21 AA021223NIA NIH HHS 1R01 AG23522NIA NIH HHS AG023629NIA NIH HHS AG13196NIA NIH HHS AG1764406S1NIA NIH HHS HHSN271201100004CNIDA NIH HHS F32DA024920NIDDK NIH HHS P30 DK063491NIDDK NIH HHS U01 DK062418NIMHD NIH HHS P20 MD006899NIMHD NIH HHS P20MD006899NINDS NIH HHS R01 NS39987Wellcome Trust 064947/Z/01/ZWellcome Trust 076113Wellcome Trust 078557Wellcome Trust 081081/Z/06/ZWellcome Trust 090532Wellcome Trust 090532/Z/09/ZWellcome Trust 092731Wellcome Trust 102215Wellcome Trust WT087997MAWellcome Trust WT088806WHI NIH HHS HHSN268200900009CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

objectiveTo use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.

designMendelian randomisation meta-analysis of 56 epidemiological studies.

participants261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers.

main outcome measuresOdds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption.

resultsCarriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m(2)). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)).

conclusionsIndividuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.

Indexed as

Polymorphism, Single NucleotideAdultAgedAlcohol DehydrogenaseAlcohol DrinkingBiomarkersCoronary DiseaseFemaleGenetic MarkersGenotypeHumansMaleMendelian Randomization AnalysisMiddle AgedModels, StatisticalStrokeADH1B protein, humanAlcohol DehydrogenaseBiomarkersGenetic Markers

Identifiers

PMID25011450
PMCPMC4091648
OpenAlexW2109003937

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.