ArticleDementia and geriatric cognitive disorders2014
Total cholesterol and neuropsychiatric symptoms in Alzheimer's disease: the impact of total cholesterol level and gender.
Article in Dementia and geriatric cognitive disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Precision medicine for Alzheimer's disease in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Meta meta-analysis of cardiovascular risk factors in Alzheimer's disease.eNeurologicalSci · 2025Review
- Impact of diabetes mellitus on the risk of Alzheimer's disease: a mendelian randomization study.BMC neurology · 2024Article
- Review
- Cholesterol and Alzheimer's Disease Risk: A Meta-Meta-Analysis.Brain sciences · 2020Review
- Article
- Amyloid Beta Peptides Affect Pregnenolone and Pregnenolone Sulfate Levels in PC-12 and SH-SY5Y Cells Depending on Cholesterol.Neurochemical research · 2016Article
- Total testosterone and neuropsychiatric symptoms in elderly men with Alzheimer's disease.Alzheimer's research & therapy · 2015Article
- Blood lipids as accessible biomarkers for early dementia risk screening: Bridging diagnostic gaps in resource-limited settings.Journal of Alzheimer's disease reportsReview
- Investigation of the Effects of Biochemical Parameters on Alzheimer's Disease.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundNeuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are a major factor in nursing home placement and a primary cause of stress for caregivers. Elevated cholesterol has been linked to psychiatric disorders and has been shown to be a risk factor for AD and to impact disease progression. The present study investigated the relationship between cholesterol and NPS in AD.
methodsData on cholesterol and NPS from 220 individuals (144 females, 76 males) with mild-to-moderate AD from the Texas Alzheimer's Research and Care Consortium (TARCC) cohort were analyzed. The total number of NPS and symptoms of hyperactivity, psychosis, affect and apathy were evaluated. Groups based on total cholesterol (TC; ≥200 vs. <200 mg/dl) were compared with regard to NPS. The impact of gender was also assessed.
resultsIndividuals with high TC had lower MMSE scores as well as significantly more NPS and more symptoms of psychosis. When stratified by gender, males with high TC had significantly more NPS than females with high TC or than males or females with low TC.
conclusionThe role of elevated cholesterol in the occurrence of NPS in AD appears to be gender and symptom specific. A cross-validation of these findings will have implications for possible treatment interventions, especially for males with high TC.
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Registered trials
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