ArticleBehaviour research and therapy2014
Extinction of cue-evoked drug-seeking relies on degrading hierarchical instrumental expectancies.
Article in Behaviour research and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Cigarette smoking and depression comorbidity: systematic review and proposed theoretical model.Addiction (Abingdon, England) · 2017Pooled it
- Plain cigarette packs do not exert Pavlovian to instrumental transfer of control over tobacco-seeking.Addiction (Abingdon, England) · 2015Trial
- Measuring cue-elicited responding in the context of gaming and online shopping: Validity and reliability of a short Pavlovian-to-instrumental transfer paradigm.Scientific reports · 2025Article
- Pavlovian to instrumental transfer of control over fight or flight decisions.NPJ science of learning · 2025Article
- Modifying Pavlovian-to-instrumental transfer by approach avoidance training in healthy subjects: a proof of concept study.Scientific reports · 2023Article
- Food cue reactivity: Neurobiological and behavioral underpinnings.Reviews in endocrine & metabolic disorders · 2022Review
- Sensory-Specific Satiety Dissociates General and Specific Pavlovian-Instrumental Transfer.Frontiers in behavioral neuroscience · 2022Article
- Anhedonia in Nicotine Dependence.Current topics in behavioral neurosciences · 2022Review
- Human appetitive Pavlovian-to-instrumental transfer: a goal-directed account.Psychological research · 2021Review
- Appetitive traits as targets for weight loss: The role of food cue responsiveness and satiety responsiveness.Physiology & behavior · 2020Review
- Relative expected value of drugs versus competing rewards underpins vulnerability to and recovery from addiction.Behavioural brain research · 2020Review
- Does acute stress influence the Pavlovian-to-instrumental transfer effect? Implications for substance use disorders.Psychopharmacology · 2020Article
- Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Studying Gambling Behaviors and Responsible Gambling Tools in a Simulated Online Casino Integrated With Amazon Mechanical Turk: Development and Initial Validation of Survey Data and Platform Mechanics of the Frescati Online Research Casino.Frontiers in psychiatry · 2020Article
- Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers: Behavioral, Neural and Polygenic Correlates.Journal of clinical medicine · 2019Article
- Pavlovian to Instrumental Transfer Responses Do Not Correlate With Addiction-Like Behavior in Rats.Frontiers in behavioral neuroscience · 2019Article
- Compulsivity in Alcohol Use Disorder and Obsessive Compulsive Disorder: Implications for Neuromodulation.Frontiers in behavioral neuroscience · 2019Article
- Expected Value of Control and the Motivational Control of Habitual Action.Frontiers in psychology · 2019Article
- Motivational sensitivity of outcome-response priming: Experimental research and theoretical models.Psychonomic bulletin & review · 2018Review
- Associative mechanisms involved in specific Pavlovian-to-instrumental transfer in human learning tasks.Quarterly journal of experimental psychology (2006) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
There has long been need for a behavioural intervention that attenuates cue-evoked drug-seeking, but the optimal method remains obscure. To address this, we report three approaches to extinguish cue-evoked drug-seeking measured in a Pavlovian to instrumental transfer design, in non-treatment seeking adult smokers and alcohol drinkers. The results showed that the ability of a drug stimulus to transfer control over a separately trained drug-seeking response was not affected by the stimulus undergoing Pavlovian extinction training in experiment 1, but was abolished by the stimulus undergoing discriminative extinction training in experiment 2, and was abolished by explicit verbal instructions stating that the stimulus did not signal a more effective response-drug contingency in experiment 3. These data suggest that cue-evoked drug-seeking is mediated by a propositional hierarchical instrumental expectancy that the drug-seeking response is more likely to be rewarded in that stimulus. Methods which degraded this hierarchical expectancy were effective in the laboratory, and so may have therapeutic potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.