Evidence map›Paper›PMID 25011104›Full record

ReviewCell host & microbe2014

Interactions between HIV-1 and the cell-autonomous innate immune system.

Greg J Towers, Mahdad Noursadeghi

Abstract readReview
In one paragraph

Review in Cell host & microbe, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. A new perspective on HIV: effects of HIV on brain-heart axis.Frontiers in cardiovascular medicine · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Similarities and differences between HIV and SARS-CoV-2.International journal of medical sciences · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. SHP-1 suppresses the antiviral innate immune response by targeting TRAF3.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  17. A Role of Intracellular Toll-Like Receptors (3, 7, and 9) in Response toInternational journal of molecular sciences · 2020
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Greg J TowersDivision of Infection and Immunity, University College London, London W1CE 6BT, UK. Electronic address: g.towers@ucl.ac.uk.
Mahdad NoursadeghiDivision of Infection and Immunity, University College London, London W1CE 6BT, UK.

Funding

Medical Research Council G0501446Medical Research Council G0801172Medical Research Council G0900950Medical Research Council G9721629Wellcome Trust 090940
6 · The paper itself

Abstract

HIV-1 was recognized as the cause of AIDS in humans in 1984. Despite 30 years of intensive research, we are still unraveling the molecular details of the host-pathogen interactions that enable this virus to escape immune clearance and cause immunodeficiency. Here we explore a series of recent studies that consider how HIV-1 interacts with the cell-autonomous innate immune system as it navigates its way in and out of host cells. We discuss how these studies improve our knowledge of HIV-1 and host biology as well as increase our understanding of transmission, persistence, and immunodeficiency and the potential for therapeutic or prophylactic interventions.

Indexed as

Host-Pathogen InteractionsImmune EvasionImmunity, InnateHIV-1Humans

Identifiers

PMID25011104
PMCPMC4096382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.