Evidence map›Paper›PMID 25011019›Full record

Trial reportHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme2015

Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D.

I Sinha-Hikim, P Duran, R Shen, M Lee, T C Friedman, M B Davidson

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00876928 (Effect of Vitamin D Supplementation on Pre-Diabetes in a Minority Population), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00876928 nacompletednot on this map

Effect of Vitamin D Supplementation on Pre-Diabetes in a Minority Population

TypeinterventionalSponsorCharles Drew University of Medicine and ScienceRan2009 to 2012Enrolled117ConditionsPre-diabetesArmsvitamin D, placebo
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  18. Vitamin D Deficiency is Associated With Increased Plasminogen Activator Inhibitor 1/Plasminogen Activator Inhibitor 2 Ratio in Pregnancy.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
  19. Vitamin D and inflammation.Dermato-endocrinology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

I Sinha-HikimDepartment of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
P DuranDepartment of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
R ShenDepartment of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
M LeeDepartment of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
T C FriedmanDepartment of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
M B DavidsonDepartment of Internal Medicine, Division of Endocrinology, Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.
University of California, Los Angeles · USCharles R. Drew University of Medicine and Science · US

Funding

Workshop for Junior Biostatisticians in Health ResearchU54MD007598 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI Ali Andalibi, Jose A Torres-Ruiz · 2012 to 2026
$60.0M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
YQ MICRODELETIONS AND MALE INFERTILITYP20RR011145 · NCRR · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI NORRIS, KEITH C · 1995 to 2009
$17.0M
VITAMIN D STIMULATES CARDIAC DIFFERENTIATIONU54RR026138 · NCRR · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI NORRIS, KEITH C · 2009 to 2011
$14.0M
Drew MIDARP (Infrastructure in Drug Abuse Research)R24DA017298 · NIDA · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI FRIEDMAN, THEODORE C · 2004 to 2018
$5.0M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCRR NIH HHS P20 RR011145NCRR NIH HHS U54 RR026138NIDA NIH HHS R24 DA017298NIDA NIH HHS R24DA017298NIMHD NIH HHS U54 MD007598NIMHD NIH HHS U54MD007598
6 · The paper itself

Abstract

Low vitamin D levels are associated with minority subjects, the metabolic syndrome, and inflammation. The effect of vitamin D supplementation on markers of inflammation has not been well studied. The aim of the study was to evaluate the effects of high doses of vitamin D supplementation for 1 year on serum biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Latino (n=69) and African-American (n=11) subjects who had both pre-diabetes and hypovitaminosis D with a mean age of 52.0 years, a BMI of 32.7 kg/m(2), and 70% of whom were females, were randomized to receive weekly doses (mean±SD) of vitamin D (85 300 IU±16 000) or placebo oil for 1 year. Serum levels of interleukin-6, tumor necrosis factor, highly sensitive C-reactive protein), plasminogen activator inhibitor 1, and insulin-like growth factor-1 were measured at baseline, 6, and 12 months. Serum 25-OH vitamin D levels of 22 ng/ml at baseline quickly rose to nearly 70 ng/ml in subjects receiving vitamin D and did not change in the placebo group. Two-way repeated measures ANOVA showed no differences between the 2 groups in any of the 5 selected parameters. High dose vitamin D supplementation for 1 year in minority subjects with pre-diabetes and hypovitaminosis D failed to affect serum biomarkers of inflammation.Clinical trial reg. no.: NCT00876928, clinicaltrials.gov.

Indexed as

Black or African AmericanHispanic or LatinoAdultBiomarkersBody Mass IndexC-Reactive ProteinDietary SupplementsFemaleHumansInflammationInsulin-Like Growth Factor IInterleukin-6MaleMiddle AgedPlacebosPlasminogen Activator Inhibitor 125-hydroxyvitamin DBiomarkersC-Reactive ProteinInsulin-Like Growth Factor IInterleukin-6PlacebosPlasminogen Activator Inhibitor 1Vitamin D

Identifiers

PMID25011019
PMCPMC4648252
OpenAlexW2045865599

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.