ArticleJournal of neurotrauma2015
Acute alcohol intoxication and long-term outcome in patients with traumatic brain injury.
Article in Journal of neurotrauma, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmacologic Neuroprotection for Functional Outcomes After Traumatic Brain Injury: A Systematic Review of the Clinical Literature.CNS drugs · 2016Pooled it
- Early Hyperosmolarity and Favorable Outcome in Severe Traumatic Brain Injury? Take it with a Grain of Salt.Neurocritical care · 2024Article
- Alcohol-Intoxicated Patients With Blunt Trauma and Head Injuries Have Better Outcomes Than Sober Patients.Cureus · 2024Article
- Injury Patterns after Falling down Stairs-High Ratio of Traumatic Brain Injury under Alcohol Influence.Journal of clinical medicine · 2022Article
- Traumatic brain injury and alcohol intoxication: effects on injury patterns and short-term outcome.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- Factors with the strongest prognostic value associated with in-hospital mortality rate among patients operated for acute subdural and epidural hematoma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2021Article
- The role of alcohol and other drugs on emergency department traumatic injury mortality in the United States.Drug and alcohol dependence · 2021Article
- Differential effect of ethanol intoxication on peripheral markers of cerebral injury in murine blunt traumatic brain injury.Burns & trauma · 2021Article
- Anti-inflammatory Effects of Alcohol Are Associated with JNK-STAT3 Downregulation in anDisease markers · 2021Article
- Pre-injury health status and excess mortality in persons with traumatic brain injury: A decade-long historical cohort study.Preventive medicine · 2020Article
- Acute alcohol intoxication as a confounding factor for mild traumatic brain injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Focus on "The German TraumaRegister DGUEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- The influence of alcohol on the outcome of trauma patients: a matched-pair analysis of the TraumaRegister DGUEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- The alcohol-intoxicated trauma patient: impact on imaging and radiation exposure.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019Article
- Patient mortality following alcohol use and trauma: a propensity-matched analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019Article
- Circulating Extracellular Vesicles and Their miR "Barcode" Differentiate Alcohol Drinkers With Liver Injury and Those Without Liver Injury in Severe Trauma Patients.Frontiers in medicine · 2019Article
- Executive (dys)function after traumatic brain injury: special considerations for behavioral pharmacology.Behavioural pharmacology · 2018Review
- Association of Alcohol With Mortality After Traumatic Brain Injury.American journal of epidemiology · 2018Article
- Evaluation of novel computerized tomography scoring systems in human traumatic brain injury: An observational, multicenter study.PLoS medicine · 2017Observational
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of blood alcohol concentration (BAC) on outcome after traumatic brain injury (TBI) is controversial. We sought to assess the independent effect of positive BAC on long-term outcome in patients with TBI treated in the intensive care unit (ICU). We performed a retrospective analysis of 405 patients with TBI, admitted to the ICU of a large urban Level 1 trauma center between January 2009 and December 2012. Outcome was six-month mortality and unfavorable neurological outcome (defined as a Glasgow Outcome Scale score of 1 [death], 2, [vegetative state], or 3 [severe disability]). Patients were categorized by admission BAC into: no BAC (0.0‰; n=99), low BAC (<2.3‰; n=140) and high BAC (≥2.3‰; n=166). Logistic regression analysis, adjusting for baseline risk and severity of illness, was used to assess the independent effect of BAC on outcome (using the no BAC group as the reference). Overall six-month mortality was 25% and unfavorable outcome was 46%. Multivariate analysis showed low BAC to independently reduce risk of six-month mortality compared with no BAC (low BAC adjusted odds ratio [AOR] 0.41, 95% confidence interval [CI] 0.19-0.88, p=0.021) and high BAC (AOR 0.58, 95% CI 0.29-1.15, p=0.120). Furthermore, a trend towards reduced risk of six-month unfavorable neurological outcome for patients with positive BAC, compared to patients with negative BAC, was noted, although this did not reach statistical significance (low BAC AOR 0.65, 95% CI 0.34-1.22, p=0.178, and high BAC AOR 0.59, 95% CI 0.32-1.09, p=0.089). In conclusion, low admission BAC (<2.3‰) was found to independently reduce risk of six-month mortality for patients with TBI, and a trend towards improved long-term neurological outcome was found for BAC-positive patients. The role of alcohol as a neuroprotective agent warrants further studies.
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