ArticlePLoS genetics2014
Arabidopsis DELLA protein degradation is controlled by a type-one protein phosphatase, TOPP4.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 96 citations in OpenAlex.
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The COBRA-Like9 from Glycine tabacina enhanced salt tolerance in cultivated soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Protein Phosphorylation: An Essential Role in Shoot Apical Meristem Homeostasis.Plants (Basel, Switzerland) · 2026Review
- CDK8 phosphorylation of DELLA limits Mediator recruitment in gibberellin signaling.bioRxiv : the preprint server for biology · 2026Article
- Structure-guided optimization of SLY1 expression and purification in Escherichia coli.Protein science : a publication of the Protein Society · 2026Article
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- Membrane-associated DELLA degradation modulates growth under carbon/nitrogen imbalance.The Plant cell · 2026Article
- Genomic Insights into Adaptation ofPlants (Basel, Switzerland) · 2026Article
- Type one protein phosphatases (TOPPs) catalyze EIN2 dephosphorylation to regulate ethylene signaling inScience advances · 2026Article
- GhTOPP4aD and GhRAF36 inversely regulate cotton (Gossypium hirsutum) response to ABA and salt stress through reversible phosphorylation of GhABI1.Plant biotechnology journal · 2025Article
- The Wheat Intrinsically Disordered ProteinBiomolecules · 2025Article
- Type One Protein Phosphatase 4aD Negatively Regulates Cotton (International journal of molecular sciences · 2025Article
- Article
- PHOSPHATASE 2A dephosphorylates PHYTOCHROME-INTERACTING FACTOR3 to modulate photomorphogenesis in Arabidopsis.The Plant cell · 2024Article
- Phosphorylation activates master growth regulator DELLA by promoting histone H2A binding at chromatin in Arabidopsis.Nature communications · 2024Article
- GSK3 phosphorylates and regulates the Green Revolution protein Rht-B1b to reduce plant height in wheat.The Plant cell · 2023Article
- The role of forkhead-associated (FHA)-domain proteins in plant biology.Plant molecular biology · 2023Review
- Type one protein phosphatase regulates fixed-carbon starvation-induced autophagy in Arabidopsis.The Plant cell · 2022Article
- Wheat genomic study for genetic improvement of traits in China.Science China. Life sciences · 2022Review
- Rice protein phosphatase 1 regulatory subunits OsINH2 and OsINH3 participate actively in growth and adaptive responses under abscisic acid.Frontiers in plant science · 2022Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gibberellins (GAs) are a class of important phytohormones regulating a variety of physiological processes during normal plant growth and development. One of the major events during GA-mediated growth is the degradation of DELLA proteins, key negative regulators of GA signaling pathway. The stability of DELLA proteins is thought to be controlled by protein phosphorylation and dephosphorylation. Up to date, no phosphatase involved in this process has been identified. We have identified a dwarfed dominant-negative Arabidopsis mutant, named topp4-1. Reduced expression of TOPP4 using an artificial microRNA strategy also resulted in a dwarfed phenotype. Genetic and biochemical analyses indicated that TOPP4 regulates GA signal transduction mainly via promoting DELLA protein degradation. The severely dwarfed topp4-1 phenotypes were partially rescued by the DELLA deficient mutants rga-t2 and gai-t6, suggesting that the DELLA proteins RGA and GAI are required for the biological function of TOPP4. Both RGA and GAI were greatly accumulated in topp4-1 but significantly decreased in 35S-TOPP4 transgenic plants compared to wild-type plants. Further analyses demonstrated that TOPP4 is able to directly bind and dephosphorylate RGA and GAI, confirming that the TOPP4-controlled phosphorylation status of DELLAs is associated with their stability. These studies provide direct evidence for a crucial role of protein dephosphorylation mediated by TOPP4 in the GA signaling pathway.
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