Trial reportEuropean journal of anaesthesiology2015
Alerting thresholds for the prevention of intraoperative awareness with explicit recall: a secondary analysis of the Michigan Awareness Control Study.
Trial report in European journal of anaesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00689091 (A Prospective, Randomized, Controlled Trial Comparing Bispectral Index Monitoring to Electronic Alerts for Prevention of Awareness During Anesthesia in the General Population), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Randomized, Controlled Trial Comparing Bispectral Index Monitoring to Electronic Alerts for Prevention of Awareness During Anesthesia in the General Population
Who cites it
4 citing papers in PubMed, 19 citations in OpenAlex.
- [Study of functional connectivity during anesthesia based on sparse partial least squares].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Comment on "Depth of Anesthesia as a Risk Factor for Perioperative Morbidity".Anesthesiology research and practice · 2015Article
- Intraoperative neurophysiological monitoring team's communiqué with anesthesia professionals.Journal of anaesthesiology, clinical pharmacologyArticle
- Awareness with Recall: Review and Guide to Electroencephalographic Depth-of-Anesthesia Monitoring.Missouri medicineArticle
Corrections and comments
- Commented on by
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIntraoperative awareness with explicit recall is a potentially devastating complication of surgery that has been attributed to low anaesthetic concentrations in the vast majority of cases. Past studies have proposed the determination of an adequate dose for general anaesthetics that could be used to alert providers of potentially insufficient anaesthesia. However, there have been no systematic analyses of appropriate thresholds to develop population-based alerting algorithms for preventing intraoperative awareness.
objectiveTo identify a threshold for intraoperative alerting that could be applied for the prevention of awareness with explicit recall.
designSecondary analysis of a randomised controlled trial (Michigan Awareness Control Study).
settingThree hospitals at a tertiary care centre in the USA. PATIENTS: Unselected patients presenting for surgery under general anaesthesia.
interventionsAlerts based on end-tidal anaesthetic concentration or bispectral index values.
main outcome measuresUsing case and outcomes data from the primary study, end-tidal anaesthetic concentration and bispectral index values were analysed using Youden's index and c-statistics derived from a receiver operating characteristic curve to determine a specific alerting threshold for the prevention of awareness.
resultsNo single population-based threshold that maximises sensitivity and specificity could be identified for the prevention of intraoperative awareness, using either anaesthetic concentration or bispectral index values. The c-statistic for anaesthetic concentration was 0.431 ± 0.046, and 0.491 ± 0.056 for bispectral index values.
conclusionWe could not derive a single population-based alerting threshold for the prevention of intraoperative awareness using either anaesthetic concentration or bispectral index values. These data indicate a need to move towards individualised alerting strategies in the prevention of intraoperative awareness.
trial registrationPrimary trial registration (Michigan Awareness Control Study) ClinicalTrials.gov identifier: NCT00689091.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.