ArticlePLoS neglected tropical diseases2014
Predictive tools for severe dengue conforming to World Health Organization 2009 criteria.
Article in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Prognostic Models in Patients with Dengue: A Systematic Review.The American journal of tropical medicine and hygiene · 2025Pooled it
- Clinical signs and symptoms associated with WHO severe dengue classification: a systematic review and meta-analysis.Emerging microbes & infections · 2021Pooled it
- Clinical predictors of severe dengue: a systematic review and meta-analysis.Infectious diseases of poverty · 2021Pooled it
- Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2021Pooled it
- The protective role of metformin against severe dengue disease in patients with type 2 diabetes mellitus: a preliminary report in Mexico.World journal of emergency medicine · 2025Article
- Risk Factors for Death in Patients With Dengue Fever in Dhaka, Bangladesh: A Verbal Autopsy Study.Cureus · 2025Article
- Prognostic prediction of dengue hemorrhagic fever in pediatric patients with suspected dengue infection: A multi-site study.PloS one · 2025Article
- The 2023 Dengue Outbreak in Bangladesh: Exploring the Epidemiology in Hospitalized Patients.The American journal of tropical medicine and hygiene · 2024Observational
- Pro- and anti-inflammatory cytokines signatures at different severity of dengue infection.Journal of family medicine and primary care · 2024Article
- Predictors of Clinically Significant Bleeding in Thrombocytopenic Dengue Patients Admitted to Intensive Care Unit: A Retrospective Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Therapeutic Potential of Medicinal Plants against Dengue Infection: A Mechanistic Viewpoint.ACS omega · 2022Review
- Factors associated with severe dengue in Savannakhet Province, Lao People's Democratic Republic.Nagoya journal of medical science · 2021Article
- Development of a bedside score to predict dengue severity.BMC infectious diseases · 2021Article
- Article
- Single molecule, near full-length genome sequencing of dengue virus.Scientific reports · 2020Article
- Dengue epidemic in a non-endemic zone of Bangladesh: Clinical and laboratory profiles of patients.PLoS neglected tropical diseases · 2020Article
- Determining Risk Factors for Dengue Fever Severity in Jeddah City, a Case-Control Study (2017).Polish journal of microbiology · 2020Article
- Article
- Capture-Layer Lateral Flow Immunoassay: A New Platform Validated in the Detection and Quantification of Dengue NS1.ACS omega · 2020Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDengue causes 50 million infections per year, posing a large disease and economic burden in tropical and subtropical regions. Only a proportion of dengue cases require hospitalization, and predictive tools to triage dengue patients at greater risk of complications may optimize usage of limited healthcare resources. For severe dengue (SD), proposed by the World Health Organization (WHO) 2009 dengue guidelines, predictive tools are lacking.
methodsWe undertook a retrospective study of adult dengue patients in Tan Tock Seng Hospital, Singapore, from 2006 to 2008. Demographic, clinical and laboratory variables at presentation from dengue polymerase chain reaction-positive and serology-positive patients were used to predict the development of SD after hospitalization using generalized linear models (GLMs). PRINCIPAL
findingsPredictive tools compatible with well-resourced and resource-limited settings--not requiring laboratory measurements--performed acceptably with optimism-corrected specificities of 29% and 27% respectively for 90% sensitivity. Higher risk of severe dengue (SD) was associated with female gender, lower than normal hematocrit level, abdominal distension, vomiting and fever on admission. Lower risk of SD was associated with more years of age (in a cohort with an interquartile range of 27-47 years of age), leucopenia and fever duration on admission. Among the warning signs proposed by WHO 2009, we found support for abdominal pain or tenderness and vomiting as predictors of combined forms of SD.
conclusionsThe application of these predictive tools in the clinical setting may reduce unnecessary admissions by 19% allowing the allocation of scarce public health resources to patients according to the severity of outcomes.
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