ReviewNeuroscience2014
Axon guidance in the auditory system: multiple functions of Eph receptors.
Review in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Ambient sound stimulation tunes axonal conduction velocity by regulating radial growth of myelin on an individual, axon-by-axon basis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Eph and ephrin signaling in the development of the central auditory system.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Central auditory deficits associated with genetic forms of peripheral deafness.Human genetics · 2022Review
- Article
- Segregation of Multimodal Inputs Into Discrete Midbrain Compartments During an Early Critical Period.Frontiers in neural circuits · 2022Article
- Ephrin-A3 is required for tonotopic map precision and auditory functions in the mouse auditory brainstem.The Journal of comparative neurology · 2021Article
- Axonal Projection Patterns of the Dorsal Interneuron Populations in the Embryonic Hindbrain.Frontiers in neuroanatomy · 2021Review
- Registry of Compartmental Ephrin-B3 Guidance Patterns With Respect to Emerging Multimodal Midbrain Maps.Frontiers in neuroanatomy · 2021Article
- Multi-sensory (auditory and somatosensory) pre-pulse inhibition in mice.Physiology & behavior · 2020Article
- Abnormal development of auditory responses in the inferior colliculus of a mouse model of Fragile X Syndrome.Journal of neurophysiology · 2020Article
- Cellular and Widefield Imaging of Sound Frequency Organization in Primary and Higher Order Fields of the Mouse Auditory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Caspase-3 Cleaves Extracellular Vesicle Proteins During Auditory Brainstem Development.Frontiers in cellular neuroscience · 2020Article
- Shaping of discrete auditory inputs to extramodular zones of the lateral cortex of the inferior colliculus.Brain structure & function · 2019Article
- Neurod1 Is Essential for the Primary Tonotopic Organization and Related Auditory Information Processing in the Midbrain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Alignment of EphA4 and ephrin-B2 expression patterns with developing modularity in the lateral cortex of the inferior colliculus.The Journal of comparative neurology · 2018Article
- Talking back: Development of the olivocochlear efferent system.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Modular-extramodular organization in developing multisensory shell regions of the mouse inferior colliculus.The Journal of comparative neurology · 2017Article
- Gene, cell, and organ multiplication drives inner ear evolution.Developmental biology · 2017Review
- Connectional Modularity of Top-Down and Bottom-Up Multimodal Inputs to the Lateral Cortex of the Mouse Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The neural pathways of the auditory system underlie our ability to detect sounds and to transform amplitude and frequency information into rich and meaningful perception. While it shares some organizational features with other sensory systems, the auditory system has some unique functions that impose special demands on precision in circuit assembly. In particular, the cochlear epithelium creates a frequency map rather than a space map, and specialized pathways extract information on interaural time and intensity differences to permit sound source localization. The assembly of auditory circuitry requires the coordinated function of multiple molecular cues. Eph receptors and their ephrin ligands constitute a large family of axon guidance molecules with developmentally regulated expression throughout the auditory system. Functional studies of Eph/ephrin signaling have revealed important roles at multiple levels of the auditory pathway, from the cochlea to the auditory cortex. These proteins provide graded cues used in establishing tonotopically ordered connections between auditory areas, as well as discrete cues that enable axons to form connections with appropriate postsynaptic partners within a target area. Throughout the auditory system, Eph proteins help to establish patterning in neural pathways during early development. This early targeting, which is further refined with neuronal activity, establishes the precision needed for auditory perception.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.