ArticleJournal of perinatology : official journal of the California Perinatal Association2014
The ontogeny of cerebrovascular pressure autoregulation in premature infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 62 citations in OpenAlex.
- Intraventricular hemorrhage in extremely low birth weight infants: frequency and duration of impaired cerebrovascular reactivity.Pediatric research · 2026Article
- Macro- and microcirculation characteristics in the territory of the anterior cerebral artery in infants with congenital heart diseases.Heart and vessels · 2025Observational
- Systemic hypotension and patterns of cerebral blood perfusion in newborns.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Impaired Cerebral Autoregulation in Children.Pediatric neurology · 2025Review
- Third-Trimester Development of Central Autonomic Network Connectivity Is Altered in an Extrauterine Environment.Neonatology · 2025Article
- Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Comparison of Near-Infrared Spectroscopy-Based Cerebral Autoregulatory Indices in Extremely Low Birth Weight Infants.Children (Basel, Switzerland) · 2023Article
- Pathogenesis and Prevention of Intraventricular Hemorrhage in Preterm Infants.Journal of Korean Neurosurgical Society · 2023Article
- The role of blood pressure variability indicators combined with cerebral blood flow parameters in predicting intraventricular hemorrhage in very low birth weight preterm infants.Frontiers in pediatrics · 2023Article
- Correlation between arterial blood pressures and regional cerebral oxygen saturation in preterm neonates during postnatal transition-an observational study.Frontiers in pediatrics · 2022Article
- Cerebral Blood Flow Autoregulation in Offspring From Experimentally Preeclamptic Rats and the Effect of Age.Frontiers in physiology · 2022Article
- The impact of initial hematocrit values after birth on peri-/intraventricular hemorrhage in extremely low birth weight neonates.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Neonatal NIRS monitoring: recommendations for data capture and review of analytics.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Assessing key clinical parameters before and after intraventricular hemorrhage in very preterm infants.European journal of pediatrics · 2020Article
- Maturation of Intestinal Oxygenation: A Review of Mechanisms and Clinical Implications for Preterm Neonates.Frontiers in pediatrics · 2020Review
- Cerebral Hemodynamics Are Not Affected by the Size of the Patent Ductus Arteriosus.Neonatology · 2020Article
- Article
- Beyond Anesthesia Toxicity: Anesthetic Considerations to Lessen the Risk of Neonatal Neurological Injury.Anesthesia and analgesia · 2019Review
- Exploring early human brain development with structural and physiological neuroimaging.NeuroImage · 2019Review
- Neonatal cerebrovascular autoregulation.Pediatric research · 2018Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo quantify cerebrovascular autoregulation as a function of gestational age (GA) and across the phases of the cardiac cycle. STUDY
designThe present study is a hypothesis-generating re-analysis of previously published data. Premature infants (n=179) with a GA range of 23 to 33 weeks were monitored with umbilical artery catheters and transcranial Doppler insonation of the middle cerebral artery for 1-h sessions over the first week of life. Autoregulation was quantified by three methods, as a moving correlation coefficient between: (1) systolic arterial blood pressure (ABP) and systolic cerebral blood flow (CBF) velocity (Sx); (2) mean ABP and mean CBF velocity (Mx); and (3) diastolic ABP and diastolic CBF velocity (Dx). Comparisons of individual and cohort cerebrovascular pressure autoregulation were made across GA for each aspect of the cardiac cycle.
resultsSystolic, mean and diastolic ABP increased with GA (r=0.3, 0.4 and 0.4; P<0.0001). Systolic CBF velocity was pressure-passive in infants with the lowest GA, and Sx decreased with advancing GA (r=-0.3; P<0.001), indicating increased capacity for cerebral autoregulation during systole during development. By contrast, Dx was elevated, indicating dysautoregulation, in all subjects and showed minimal change with advancing GA (r=-0.06; P=0.05). Multivariate analysis confirmed that both GA (P<0.001) and 'effective cerebral perfusion pressure' (ABP minus critical closing pressure (CrCP); P<0.01) were associated with Sx.
conclusionPremature infants have low and usually pressure-passive diastolic CBF velocity. By contrast, the regulation of systolic CBF velocity by pressure autoregulation developed in this cohort between 23 and 33 weeks GA. Elevated effective cerebral perfusion pressure derived from the CrCP was associated with dysautoregulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.