Evidence map›Paper›PMID 25010223›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2014

One size does not fit all: why universal decolonization strategies to prevent methicillin-resistant Staphylococcus aureus colonization and infection in adult intensive care units may be inappropriate for neonatal intensive care units.

M U Nelson, M J Bizzarro, L M Dembry, R S Baltimore, P G Gallagher

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

  1. Mupirocin forPediatrics · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

M U NelsonDivision of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
M J BizzarroDivision of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
L M Dembry1] Division of Infectious Disease, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA [2] Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA [3] Department of Infection Control, Yale-New Haven Hospital, New Haven, CT, USA.
R S Baltimore1] Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA [2] Department of Infection Control, Yale-New Haven Hospital, New Haven, CT, USA [3] Division of Infectious Disease, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
P G Gallagher1] Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA [2] Department of Pathology, Yale University School of Medicine, New Haven, CT, USA [3] Department of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Yale University · US

Funding

RESEARCH IN PERINATAL MEDICINET32HD007094 · NICHD · YALE UNIVERSITY · PI GALLAGHER, PATRICK G · 1985 to 2015
$3.6M
NICHD NIH HHS T32 HD007094
6 · The paper itself

Abstract

The REDUCE MRSA Trial (Randomized Evaluation of Decolonization vs Universal Clearance to Eliminate Methicillin-Resistant Staphylococcus aureus), a large multicenter, randomized controlled trial in adult intensive care units (ICUs), found universal decolonization to be more effective than surveillance and isolation procedures with or without targeted decolonization for reducing rates of MRSA-positive clinical cultures. The Agency for Healthcare Research and Quality and the Centers for Disease Control and Prevention subsequently published protocols for implementing universal decolonization in ICUs based on the trial's methods. Caution should be exercised before widely adopting these procedures in neonatal intensive care units (NICUs), particularly strategies that involve bathing with chlorhexidine and mupirocin application due to the potential for adverse events in their unique patient population, especially preterm infants. Large multicenter trials in the NICUs are needed to evaluate the efficacy, short- and long-term safety, and cost effectiveness of these strategies prior to their widespread implementation.

Indexed as

Intensive Care UnitsIntensive Care Units, NeonatalAdultChlorhexidineHumansInfant, NewbornInfant, Premature, DiseasesMethicillin-Resistant Staphylococcus aureusMupirocinStaphylococcal InfectionsChlorhexidineMupirocin

Identifiers

PMID25010223
PMCPMC4152419
OpenAlexW2038877709

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.