ArticleThe American journal of the medical sciences2014
Growing up or growing old? Cellular aging linked with testosterone reactivity to stress in youth.
Article in The American journal of the medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Accelerated telomere shortening: Tracking the lasting impact of early institutional care at the cellular level.Psychiatry research · 2016Trial
- Age and gender intersectionality among African Americans: Salivary uric acid is associated with shorter telomere length in younger adults and men.Psychoneuroendocrinology · 2025Article
- The social context of educational effort - implications for psychological and physiological health in adolescence.Psychoneuroendocrinology · 2025Article
- No effect of testosterone or sexual ornamentation on telomere dynamics: A case study and meta-analyses.Ecology and evolution · 2024Article
- The interaction of socioeconomic stress and race on telomere length in children: A systematic review and meta-analysis.SSM - population health · 2023Article
- Sexual Dimorphism in Telomere Length in Childhood Autism.Journal of autism and developmental disorders · 2023Article
- Longitudinal effects of family psychopathology and stress on pubertal maturation and hormone coupling in adolescent twins.Developmental psychobiology · 2021Article
- Testosterone and hippocampal trajectories mediate relationship of poverty to emotion dysregulation and depression.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Early Puberty and Telomere Length in Preadolescent Girls and Mothers.The Journal of pediatrics · 2020Article
- Testosterone reactivity is associated with reduced neural response to reward in early adolescence.Behavioural brain research · 2020Article
- Adverse Childhood Experiences: Implications for Offspring Telomere Length and Psychopathology.The American journal of psychiatry · 2020Article
- Stress, Professional Lifestyle, and Telomere Biology in Elite Athletes: A Growing Trend in Psychophysiology of Sport.Frontiers in psychology · 2020Article
- Telomere Biology in Mood Disorders: An Updated, Comprehensive Review of the Literature.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Article
- Internalizing Mental Disorders and Accelerated Cellular Aging Among Perinatally HIV-Infected Youth in Uganda.Frontiers in genetics · 2019Article
- A scoping systematic review of social stressors and various measures of telomere length across the life course.Ageing research reviews · 2018Article
- The Effect of Psychological Stress on Salivary Testosterone in Puberty Children.Open access Macedonian journal of medical sciences · 2018Article
- Relationships of sex hormone levels with leukocyte telomere length in Black, Hispanic, and Asian/Pacific Islander postmenopausal women.Journal of diabetes · 2018Observational
- Social evaluative threat with verbal performance feedback alters neuroendocrine response to stress.Hormones and behavior · 2017Article
- Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth.Endocrine connections · 2016Article
- Associations of Buccal Cell Telomere Length with Daily Intake of β-Carotene or α-Tocopherol Are Dependent on Carotenoid Metabolism-related Gene Polymorphisms in Healthy Japanese Adults.The journal of nutrition, health & aging · 2016Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGiven the established relation between testosterone and aging in older adults, we tested whether buccal telomere length (TL), an established cellular biomarker of aging, was associated with testosterone levels in youth.
methodsChildren, mean age 10.2 years, were recruited from the greater New Orleans area, and salivary testosterone was measured diurnally and during an acute stressor. Buccal TL was measured using monochrome multiplex quantitative real-time polymerase chain reaction. Testosterone and TL data were available on 77 individuals. The association between buccal TL and testosterone was tested using multivariate generalized estimating equations to account for clustering of children within families.
resultsGreater peak testosterone levels (β = -0.87, P < 0.01) and slower recovery (β = -0.56, P < 0.01) and reactivity (β = -1.22, P < 0.01) following a social stressor were significantly associated with shorter buccal TL after controlling for parental age at conception, child age, sex, sociodemographic factors and puberty. No association was initially present between diurnal measurements of testosterone or morning basal testosterone levels and buccal TL. Sex significantly moderated the relation between testosterone reactivity and buccal TL.
conclusionsThe association between testosterone and buccal TL supports gonadal maturation as a developmentally sensitive biomarker of aging within youth. As stress levels of testosterone were significantly associated with buccal TL, these findings are consistent with the growing literature linking stress exposure and accelerated maturation. The lack of association of diurnal testosterone or morning basal levels with buccal TL bolsters the notion of a shared stress-related maturational mechanism between cellular stress and the hypothalamic pituitary gonadal axis. These data provide novel evidence supporting the interaction of aging, physiologic stress and cellular processes as an underlying mechanism linking negative health outcomes and early life stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.