ArticlePloS one2014
Sox9 duplications are a relevant cause of Sry-negative XX sex reversal dogs.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Canine XX Disorders/Differences of Sex Development (SRY-Negative): A Potential Role for theSexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2026Review
- A Case of Disorder of Sex Development in Red Deer (<italic>Cervus elaphus</italic>).Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2026Article
- XX/XY Chimerism in Internal Genitalia of a Virilized Heifer.Animals : an open access journal from MDPI · 2022Article
- Clinical and diagnostic approach of male pseudo hermaphroditism with os-clitoris in French bulldog: A case report.Veterinary medicine and science · 2022Article
- Clinical Cytogenetics of the Dog: A Review.Animals : an open access journal from MDPI · 2021Review
- An Unusual Case of Testicular Disorder in Sex Development of Arabian Mare (64,XXAnimals : an open access journal from MDPI · 2020Article
- Analysis of XXAnimals : an open access journal from MDPI · 2020Article
- Article
- Urogenital anomalies and urinary incontinence in an English Cocker Spaniel dog with XX sex reversal.Journal of veterinary internal medicine · 2018Article
- Similar genomic proportions of copy number variation within gray wolves and modern dog breeds inferred from whole genome sequencing.BMC genomics · 2017Article
- Article
- Copy number variation in the region harboring SOX9 gene in dogs with testicular/ovotesticular disorder of sex development (78,XX; SRY-negative).Scientific reports · 2015Article
- Testis development in the absence of SRY: chromosomal rearrangements at SOX9 and SOX3.European journal of human genetics : EJHG · 2015Article
- Porcine SOX9 Gene Expression Is Influenced by an 18 bp Indel in the 5'-Untranslated Region.PloS one · 2015Article
- 46,XX testicular disorder of sexual development with SRY-negative caused by some unidentified mechanisms: a case report and review of the literature.BMC urology · 2014Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexual development in mammals is based on a complicated and delicate network of genes and hormones that have to collaborate in a precise manner. The dark side of this pathway is represented by pathological conditions, wherein sexual development does not occur properly either in the XX and the XY background. Among them a conundrum is represented by the XX individuals with at least a partial testis differentiation even in absence of SRY. This particular condition is present in various mammals including the dog. Seven dogs characterized by XX karyotype, absence of SRY gene, and testicular tissue development were analysed by Array-CGH. In two cases the array-CGH analysis detected an interstitial heterozygous duplication of chromosome 9. The duplication contained the SOX9 coding region. In this work we provide for the first time a causative mutation for the XXSR condition in the dog. Moreover this report supports the idea that the dog represents a good animal model for the study of XXSR condition caused by abnormalities in the SOX9 locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.