ReviewCurrent opinion in virology2014
Antiviral lectins as potential HIV microbicides.
Review in Current opinion in virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Article
- Targeting spike glycans to inhibit SARS-CoV2 viral entry.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Lactic acid bacterial surface display of scytovirin inhibitors for anti-ebolavirus infection.Frontiers in microbiology · 2023Article
- CH-π Interactions in Glycan Recognition.ACS chemical biology · 2021Review
- BanLec-eGFP Chimera as a Tool for Evaluation of Lectin Binding to High-Mannose Glycans on Microorganisms.Biomolecules · 2021Article
- The barley lectin, horcolin, binds high-mannose glycans in a multivalent fashion, enabling high-affinity, specific inhibition of cellular HIV infection.The Journal of biological chemistry · 2020Article
- Article
- GalNAc-Specific Soybean Lectin Inhibits HIV Infection of Macrophages through Induction of Antiviral Factors.Journal of virology · 2018Article
- Heterogeneity in glycan composition on the surface of HIV-1 envelope determines virus sensitivity to lectins.PloS one · 2018Article
- Article
- Structure and Glycan Binding of a New Cyanovirin-N Homolog.The Journal of biological chemistry · 2016Article
- Article
- Identification, Characterization, and X-ray Crystallographic Analysis of a Novel Type of Mannose-Specific Lectin CGL1 from the Pacific Oyster Crassostrea gigas.Scientific reports · 2016Article
- Article
- High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120.Marine biotechnology (New York, N.Y.) · 2016Article
- High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120.Marine biotechnology (New York, N.Y.) · 2016Article
- Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL).Acta crystallographica. Section F, Structural biology communications · 2015Article
- Bottlenecks in HIV-1 transmission: insights from the study of founder viruses.Nature reviews. Microbiology · 2015Review
- Marine lectins and their medicinal applications.Applied microbiology and biotechnology · 2015Review
- Lectins with anti-HIV activity: a review.Molecules (Basel, Switzerland) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
A growing class of potential antivirals encompasses carbohydrate-binding proteins, such as antibodies and lectins. They block virus entry into host target cells and halt virus transmission from virus-infected cells to non-infected cells, thereby preventing infection. Here, we review the structural basis for the anti-HIV activity of various lectins, describing their structures and determinants of high-affinity oligosaccharide binding. The mechanism of glycan recognition on the gp120 envelope protein by these antiviral lectins may therefore be exploited for developing agents and alternative strategies to prevent HIV transmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.