ReviewClinical pharmacology and therapeutics2014
Longitudinal inflammation, cognitive decline, and Alzheimer's disease: a mini-review.
Review in Clinical pharmacology and therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed.
- Targeting cytokine-driven neuroinflammation in Alzheimer's disease: mechanistic insights and pharmacological strategies.Inflammopharmacology · 2026Review
- Article
- Porphyromonas gingivalis Outer Membrane Vesicles-Associated DNA Triggers Inflammation by Inducing IL-6 in Astrocytes.Molecular oral microbiology · 2026Article
- [Mechanisms of cGAS-STING-mediated chronic inflammation and targeted interventions in brain aging].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Review
- Decreased hippocampal neurite density in late-middle-aged adults following prenatal exposure to higher levels of maternal inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sex-specific associations of gene expression with Alzheimer's disease neuropathology and ante-mortem cognitive performance.Nature communications · 2025Article
- Higher interleukin-6 (IL-6) is associated with decline in psychomotor processing speed but not executive functioning in older adults: Gender-specific effects.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Decreased hippocampal neurite density in late middle-aged adults following prenatal exposure to higher levels of maternal inflammation.bioRxiv : the preprint server for biology · 2025Article
- Plasma Inflammatory Biomarkers Link to Worse Cognition Among Africans With HIV.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Review
- In a circuit necessary for cognition and emotional affect, Alzheimer's-like pathology associates with neuroinflammation, cognitive and motivational deficits in the young adult TgF344-AD rat.Brain, behavior, & immunity - health · 2024Article
- DNA Methylation at C-Reactive Protein-Associated CpG Sites May Mediate the Pathway Between Educational Attainment and Cognition.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Relationship between cognitive function and phase angle measured with a bioelectrical impedance system.European geriatric medicine · 2024Article
- Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection.Clinical science (London, England : 1979) · 2023Review
- Article
- Characterizing Canadian long-term care home consumed foods and their inflammatory potential: a secondary analysis.BMC public health · 2023Article
- Neuroprotective Effect of α-Lipoic Acid against AβMolecules (Basel, Switzerland) · 2023Article
- Links between inflammation and immune functioning with cognitive status among older Americans in the Health and Retirement Study.Brain, behavior, & immunity - health · 2022Article
- Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper.Molecules (Basel, Switzerland) · 2022Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The role of inflammation in cognitive decline has generated considerable interest, although few longitudinal evaluations have been conducted. A review of the literature yields mixed findings but suggests that inflammatory dysregulation is evident and may be related to clinical outcomes. The directionality, magnitude, and progression of these associations remain unclear. Future studies employing multiple time points of inflammatory data along with Alzheimer's disease (AD) biomarkers are critical for explication of longitudinal inflammation in cognitive decline.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.