ReviewACS chemical biology2014
Recent advances in radical SAM enzymology: new structures and mechanisms.
Review in ACS chemical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- Methionine restriction constrains lipoylation and activates mitochondria for nitrogenic synthesis of amino acids.Nature communications · 2023Article
- Structure and Catalytic Mechanism of Radical SAM Methylases.Life (Basel, Switzerland) · 2022Review
- RaS-RiPPs in Streptococci and the Human Microbiome.ACS bio & med chem Au · 2022Review
- Using kinetic isotope effects to probe the mechanism of adenosylcobalamin-dependent enzymes.Methods in enzymology · 2022Article
- Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity.The Journal of biological chemistry · 2020Review
- Targeting viperin to the mitochondrion inhibits the thiolase activity of the trifunctional enzyme complex.The Journal of biological chemistry · 2020Article
- Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.The Journal of biological chemistry · 2019Article
- Nitric oxide functionalized molybdenum(0) pyrazolone Schiff base complexes: thermal and biochemical study.RSC advances · 2018Article
- Endogenous superoxide is a key effector of the oxygen sensitivity of a model obligate anaerobe.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The radical SAM protein HemW is a heme chaperone.The Journal of biological chemistry · 2018Article
- Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a "Plug and Play" Domain.Methods in enzymology · 2018Article
- Characterization of auxiliary iron-sulfur clusters in a radicalFEBS open bio · 2017Article
- Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.Biochemistry · 2017Article
- Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin.The Journal of biological chemistry · 2017Article
- BciD Is a Radical S-Adenosyl-l-methionine (SAM) Enzyme That Completes Bacteriochlorophyllide e Biosynthesis by Oxidizing a Methyl Group into a Formyl Group at C-7.The Journal of biological chemistry · 2017Article
- Does Viperin Function as a Radical S-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?The Journal of biological chemistry · 2016Article
- Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi.Nature structural & molecular biology · 2016Article
- Catalytic Promiscuity of the Radical S-adenosyl-L-methionine Enzyme NosL.Frontiers in chemistry · 2016Review
- Whither Enzymology in the Twenty First Century?Frontiers in chemistry · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The radical S-adenosylmethionine (SAM) superfamily of enzymes catalyzes an amazingly diverse variety of reactions ranging from simple hydrogen abstraction to complicated multistep rearrangements and insertions. The reactions they catalyze are important for a broad range of biological functions, including cofactor and natural product biosynthesis, DNA repair, and tRNA modification. Generally conserved features of the radical SAM superfamily include a CX3CX2C motif that binds an [Fe4S4] cluster essential for the reductive cleavage of SAM. Here, we review recent advances in our understanding of the structure and mechanisms of these enzymes that, in some cases, have overturned widely accepted mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.