Evidence map›Paper›PMID 25009781›Full record

ReviewRedox biology2014

Wine consumption and intestinal redox homeostasis.

Fiorella Biasi, Monica Deiana, Tina Guina, Paola Gamba, Gabriella Leonarduzzi, Giuseppe Poli

Open access · goldAbstract readReview
In one paragraph

Review in Redox biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 86 citations in OpenAlex.

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  17. Journal of animal science and biotechnology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Fiorella BiasiDepartment of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Orbassano, Turin 10043, Italy.
Monica DeianaDepartment of Biomedical Sciences, University of Cagliari, Cagliari 09124, Italy.
Tina GuinaDepartment of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Orbassano, Turin 10043, Italy.
Paola GambaDepartment of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Orbassano, Turin 10043, Italy.
Gabriella LeonarduzziDepartment of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Orbassano, Turin 10043, Italy.
Giuseppe PoliDepartment of Clinical and Biological Sciences, University of Turin at San Luigi Gonzaga Hospital, Orbassano, Turin 10043, Italy.
University of Turin · ITOspedale San Luigi Gonzaga · ITUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular consumption of moderate doses of wine is an integral part of the Mediterranean diet, which has long been considered to provide remarkable health benefits. Wine's beneficial effect has been attributed principally to its non-alcoholic portion, which has antioxidant properties, and contains a wide variety of phenolics, generally called polyphenols. Wine phenolics may prevent or delay the progression of intestinal diseases characterized by oxidative stress and inflammation, especially because they reach higher concentrations in the gut than in other tissues. They act as both free radical scavengers and modulators of specific inflammation-related genes involved in cellular redox signaling. In addition, the importance of wine polyphenols has recently been stressed for their ability to act as prebiotics and antimicrobial agents. Wine components have been proposed as an alternative natural approach to prevent or treat inflammatory bowel diseases. The difficulty remains to distinguish whether these positive properties are due only to polyphenols in wine or also to the alcohol intake, since many studies have reported ethanol to possess various beneficial effects. Our knowledge of the use of wine components in managing human intestinal inflammatory diseases is still quite limited, and further clinical studies may afford more solid evidence of their beneficial effects.

Indexed as

AnimalsAntioxidantsHomeostasisHumansIntestinal MucosaIntestinesMicrobiotaOxidation-ReductionPolyphenolsSignal TransductionWineAntioxidantsPolyphenolsAKT, serine/threonine protein kinase (v-akt murine thimoma viral oncogene homolog1)AntioxidantsapoB48, apolipoprotein B48CD, Crohns diseaseCOX-2, cyclooxygenase-2Cys, cysteineDSS, dextran sodium sulfateERK, extracellular signal-regulated kinaseGRP, grape reaction productGSH, reduced glutathioneGutIBD, inflammatory bowel diseaseIFN, interferonIKB, inhibitor of NF-κBIL, interleukinInflammationiNOS, inducible nitric oxide synthaseLPS, lipopolysaccharideMAPK, mitogen-activated protein kinaseNADPH, nicotinamide adenine dinucleotide phosphate reducedNF-κB, nuclear factor-κBNrf2, nuclear factor erythroid-2-related factor 2Oxidative stressPGE-2, prostaglandin E-2PolyphenolsROS, reactive oxygen speciesSIRT-1, silent mating type information regulation-1TNF-α, tumor necrosis factor alphaUC, Ulcerative ColitisWine

Identifiers

PMID25009781
PMCPMC4085343
OpenAlexW2161533419

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.